Disorders of steroid 11β-hydroxylase isozymes

Perrin C. White, Leigh Pascoe

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Steroid 11 β-hydroxylase activity in the adrenal cortex is required for the synthesis of the major glucocorticoids and mineralocorticoids, but different isozymes mediate this conversion in the zona fasciculata, where cortisol is produced, and the zona glomerulosa, the site of aldosterone synthesis. The isozyme in the latter zone also has 18-hydroxylase and 18-oxidase activities that are required for aldosterone synthesis. Mutations in the genes encoding these isozymes respectively result in defective synthesis of cortisol and aldosterone. Recombinations between the two genes that alter the regulation of the isozyme responsible for aldosterone synthesis cause an inherited form of hypertension, glucocorticoid-suppressible hyperaldosteronism.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number6
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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