Disordered and dead, but in good company: How a catalytically inactive UTX retains its function

Heankel Cantu Oliveros; Benjamin R. Sabari

doi:10.1016/j.molcel.2021.10.021

Disordered and dead, but in good company: How a catalytically inactive UTX retains its function

Heankel Cantu Oliveros, Benjamin R. Sabari

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Abstract

Shi et al. (2021) demonstrate that tumor-suppressive and developmental functions of UTX require an intrinsically disordered region (IDR) capable of condensate formation. These results provide further evidence for the functional role of IDR-mediated spatial organization in regulating gene expression in development and disease.

Original language	English (US)
Pages (from-to)	4577-4578
Number of pages	2
Journal	Molecular cell
Volume	81
Issue number	22
DOIs	https://doi.org/10.1016/j.molcel.2021.10.021
State	Published - Nov 18 2021

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2021.10.021

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title = "Disordered and dead, but in good company: How a catalytically inactive UTX retains its function",

abstract = "Shi et al. (2021) demonstrate that tumor-suppressive and developmental functions of UTX require an intrinsically disordered region (IDR) capable of condensate formation. These results provide further evidence for the functional role of IDR-mediated spatial organization in regulating gene expression in development and disease.",

author = "{Cantu Oliveros}, Heankel and Sabari, {Benjamin R.}",

note = "Funding Information: This work was supported by funding from CPRIT ( RR190090 ). B.R.S. is a member of the Molecular Cell advisory board. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

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Disordered and dead, but in good company: How a catalytically inactive UTX retains its function

Abstract

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