Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site

Medicine & Life Sciences

• X Ray Crystallography 100%
• Binding Sites 56%
• Anti-Inflammatory Agents 53%
• Proteins 26%
• human BRD4 protein 24%
• Mutagenesis 10%
• Lysine 10%
• Epigenomics 9%
• X-Rays 8%
• In Vitro Techniques 4%
• Pharmaceutical Preparations 4%
• Therapeutics 1%

Chemical Compounds

• Antiinflammatory 69%
• X-Ray Crystallography 60%
• Binding Site 51%
• Protein 30%
• Drug Target 13%
• Lysine 11%
• Disorder 10%
• X-Ray 7%