Direct palladium-catalyzed arylation of cyclopropenes

Stepan Chuprakov; Michael Rubin; Vladimir Gevorgyan

doi:10.1021/ja042380k

Direct palladium-catalyzed arylation of cyclopropenes

Stepan Chuprakov, Michael Rubin, Vladimir Gevorgyan

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The first examples of direct palladium-catalyzed arylation and heteroarylation of cyclopropenes have been demonstrated. This method allows for efficient synthesis of various tetrasubstituted cyclopropenes, incuding nonracemic cyclopropenes, which are not available via known asymmetric cyclopropenation methods. Mechanistic studies strongly suggest an electrophilic path for this Heck-type transformation.

Original language	English (US)
Pages (from-to)	3714-3715
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	11
DOIs	https://doi.org/10.1021/ja042380k
State	Published - Mar 23 2005
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja042380k

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abstract = "The first examples of direct palladium-catalyzed arylation and heteroarylation of cyclopropenes have been demonstrated. This method allows for efficient synthesis of various tetrasubstituted cyclopropenes, incuding nonracemic cyclopropenes, which are not available via known asymmetric cyclopropenation methods. Mechanistic studies strongly suggest an electrophilic path for this Heck-type transformation.",

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AU - Rubin, Michael

AU - Gevorgyan, Vladimir

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N2 - The first examples of direct palladium-catalyzed arylation and heteroarylation of cyclopropenes have been demonstrated. This method allows for efficient synthesis of various tetrasubstituted cyclopropenes, incuding nonracemic cyclopropenes, which are not available via known asymmetric cyclopropenation methods. Mechanistic studies strongly suggest an electrophilic path for this Heck-type transformation.

AB - The first examples of direct palladium-catalyzed arylation and heteroarylation of cyclopropenes have been demonstrated. This method allows for efficient synthesis of various tetrasubstituted cyclopropenes, incuding nonracemic cyclopropenes, which are not available via known asymmetric cyclopropenation methods. Mechanistic studies strongly suggest an electrophilic path for this Heck-type transformation.

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Direct palladium-catalyzed arylation of cyclopropenes

Abstract

ASJC Scopus subject areas

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