TY - JOUR
T1 - Diminishing returns, increasing risks
T2 - Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
AU - Li, Catherine
AU - Chapin, Ryan W.
AU - Mercuro, Nicholas J.
AU - Yen, Christina F.
AU - Gold, Howard S.
AU - Lee, Matthew S.L.
AU - McCoy, Christopher
N1 - Funding Information:
No financial support was provided relevant to this article.
Publisher Copyright:
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America.
PY - 2021/7/23
Y1 - 2021/7/23
N2 - In 829 hospital encounters for patients with COVID-19, 73.2% included orders for antibiotics; however, only 1.8% had respiratory cultures during the first 3 hospital days isolating bacteria. Case-control analysis of 30 patients and 96 controls found that each antibiotic day increased the risk of isolating multidrug-resistant gram-negative bacteria (MDR-GNB) in respiratory cultures by 6.5%.
AB - In 829 hospital encounters for patients with COVID-19, 73.2% included orders for antibiotics; however, only 1.8% had respiratory cultures during the first 3 hospital days isolating bacteria. Case-control analysis of 30 patients and 96 controls found that each antibiotic day increased the risk of isolating multidrug-resistant gram-negative bacteria (MDR-GNB) in respiratory cultures by 6.5%.
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U2 - 10.1017/ash.2021.173
DO - 10.1017/ash.2021.173
M3 - Article
C2 - 36168468
AN - SCOPUS:85129786240
SN - 2732-494X
VL - 1
JO - Antimicrobial Stewardship and Healthcare Epidemiology
JF - Antimicrobial Stewardship and Healthcare Epidemiology
IS - 1
M1 - e13
ER -