Dimeric pyrrole–imidazole alkaloids: Synthetic approaches and biosynthetic hypotheses

Xiao Wang, Zhiqiang Ma, Xiaolei Wang, Saptarshi De, Yuyong Ma, Chuo Chen

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The pyrrole–imidazole alkaloids are a group of structurally unique and biologically interesting marine sponge metabolites. Among them, the cyclic dimers have caught synthetic chemists' attention particularly. Numerous synthetic strategies have been developed and various biosynthetic hypotheses have been proposed for these fascinating natural products. We discuss herein the synthetic approaches and the biosynthetic insights obtained from these studies.

Original languageEnglish (US)
Pages (from-to)8628-8639
Number of pages12
JournalChemical Communications
Issue number63
StatePublished - Jul 10 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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