Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap

Xianyao Tao, Xiaoyun Pan, Gang Zhao, Mingyu Xue, Yongjun Rui

Research output: Contribution to journalArticlepeer-review

Abstract

In clinical flap practice, there are a lot of studies being done on how to promote the survival of distal random flap necrosis in the hypoxic and ischemic state. As a traditional Chinese medicine, dihydromyricetin (DHM) is crucial in preventing oxidative stress and apoptosis in a number of disorders. In this work, we examined the impact of DHM on the ability to survive of ischemia flaps and looked into its fundamental mechanism. Our results showed that DHM significantly increased the ischemic flaps' survival area, encouraged angiogenesis and blood flow, reduced oxidative stress and apoptosis, and stimulated KEAP1-Nrf2 (Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor) signaling pathways. Adeno-associated virus (AAV) upregulation of KEAP1 expression also negated the favorable effects of DHM on flap survival. By activating KEAP1-Nrf2 signaling pathways, DHM therapy promotes angiogenesis while reducing oxidative stress and apoptosis.

Original languageEnglish (US)
Pages (from-to)3893-3909
Number of pages17
JournalFood Science and Nutrition
Volume12
Issue number6
DOIs
StatePublished - Jun 2024
Externally publishedYes

Keywords

  • angiogenesis
  • apoptosis
  • dihydromyricetin
  • ischemic flap
  • oxidative stress

ASJC Scopus subject areas

  • Food Science

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