Diffusion tensor imaging of hemispheric asymmetries in the developing brain

Elisabeth A. Wilde, Stephen R. McCauley, Zili Chu, Jill V. Hunter, Erin D. Bigler, Ragini Yallampalli, Zhiyue J. Wang, Gerri Hanten, Xiaoqi Li, Marco A. Ramos, Sharjeel H. Sabir, Ana C. Vasquez, Deleene Menefee, Harvey S. Levin

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Diffusion tensor imaging (DTI) was performed in 39 right-handed children to examine structural hemispheric differences and the impact of age, socioeconomic status, and sex on these differences. Apparent diffusion coefficient (ADC) values were smaller in the left than in the right temporal, prefrontal, anterior internal capsular and the thalamic regions, and fractional anisotropy (FA) values were larger in the left than in the right internal capsule, thalamus, and cingulate. Significant region-by-sex interactions disclosed that the relation of DTI asymmetries to performance depended on sex including the relation of temporal lobes to reading comprehension and the relation of frontal lobes to solving applied mathematical problems.

Original languageEnglish (US)
Pages (from-to)205-218
Number of pages14
JournalJournal of Clinical and Experimental Neuropsychology
Issue number2
StatePublished - 2009


  • Adolescents
  • Arithmetic
  • Asymmetry
  • Brain
  • Children
  • Diffusion tensor imaging
  • Reading

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology


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