Differentiation of bone marrow-derived lymphocytes.

J. W. Uhr, E. S. Vitetta

Research output: Contribution to journalArticlepeer-review


Murine lymphocytes were enzymatically radioiodinated and the class of immunoglobulin (isotype) on the cell surface was studied as a function of differentiation and ontogeny. The results indicate that IgM is the first isotype to appear and that IgD is subsequently acquired. A proportion of IgM-bearing cells also bear IgD. The acquisition of IgD does not appear to be under the influence of the thymus or of exposure to antigen. The observations suggest a sequence of differentiation steps in which B-cells first express IgM then acquire IgD (to become "double bearers"), and eventually lose IgM. The relationship of the IgD-bearing cells to the IgG-bearing memory cells has not yet been established. The implications of these findings with regard to function and genetic organization are discussed.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalNational Cancer Institute monograph
Issue number48
StatePublished - May 1 1978

ASJC Scopus subject areas

  • Medicine(all)


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