Differential pathophysiology of bacterial translocation after thermal injury and sepsis

William G. Jones, Annabel E. Barber, Joseph P. Minei, Thomas J. Fahey, G. Tom Shires, G. Tom Shires

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Bacterial translocation (BT) occurs transiently after thermal injury and may result from an ischemic intestinal insult. To evaluate continued intestinal ischemia in the ongoing BT associated with sepsis after injury, rats were randomized to (1) 30% burn injury with Pseudomonas wound infection (BI), (2) BI + fluid resuscitation (BI + Fluid), (3) BI after allopurinol pretreatment to inhibit xanthine oxidase (BI + Allo), or (4) BI after azapropazone pretreatment to inhibit neutrophil degranulation (BI + Aza). On postburn days (PBD) 1, 4, and 7, animals were studied for evidence of BT and intestinal lipid peroxidation. BI + Fluid, BI + Allo, and BI + Aza significantly (p < 0.05) reduced rates of BT and ileal lipid peroxidation acutely after thermal injury (PBD 1) compared to BI. All four groups had equally high rates of BT associated with the onset of sepsis (PBDs 4 and 7), without evidence of further intestinal lipid peroxidation. These data indicate that the chronic gut barrier failure associated with sepsis after injury occurs independently of continued intestinal ischemia.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalAnnals of surgery
Issue number1
StatePublished - 1991

ASJC Scopus subject areas

  • Surgery


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