Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Karine Pozo; Demetra P. Kelenis; John D. Minna; Jane E. Johnson

doi:10.1158/2159-8290.CD-18-0979

Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Karine Pozo, Demetra P. Kelenis, John D. Minna, Jane E. Johnson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.

Original language	English (US)
Pages (from-to)	1216-1218
Number of pages	3
Journal	Cancer discovery
Volume	8
Issue number	10
DOIs	https://doi.org/10.1158/2159-8290.CD-18-0979
State	Published - Oct 2018

ASJC Scopus subject areas

Oncology

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title = "Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors",

abstract = "Studies in genetically engineered mouse models of neuroendocrine lung cancer suggest that differences in cells of origin underlie subtype variations in this class of cancers. These findings highlight the concept that the same driver mutations introduced into different cells of origin lead to tumors with the same histology but dramatically different metastatic programs and potentially different therapeutic responses.",

author = "Karine Pozo and Kelenis, {Demetra P.} and Minna, {John D.} and Johnson, {Jane E.}",

note = "Publisher Copyright: {\textcopyright}2018 American Association for Cancer Research.",

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AU - Kelenis, Demetra P.

AU - Minna, John D.

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Different originating cells underlie intertumoral heterogeneity in lung neuroendocrine tumors

Abstract

ASJC Scopus subject areas

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