Diagnosis and Management of Obesity Hypoventilation Syndrome in the ICU

Won Y. Lee, Babak Mokhlesi

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Obesity hypoventilation syndrome (OHS) is characterized by obesity, daytime hypercapnia, and sleep-disordered breathing in the absence of other known causes of hypercapnia. Because of the global obesity epidemic and the high prevalence of obstructive sleep apnea in the general population, critical care physicians are likely to encounter patients who have acute-on-chronic respiratory failure attributable to OHS in their clinical practice. In this review we define the clinical characteristics of OHS, review its pathophysiology, and discuss the morbidity and mortality associated with OHS. Finally, we offer treatment strategies during ICU management using noninvasive positive pressure ventilation that may guide the physician in the care of these challenging patients.

Original languageEnglish (US)
Pages (from-to)533-549
Number of pages17
JournalCritical Care Clinics
Issue number3
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Diagnosis and Management of Obesity Hypoventilation Syndrome in the ICU'. Together they form a unique fingerprint.

Cite this