Diagnosis and Management of Multiple Sclerosis: Case Studies

Douglas A. Woo, Michael J. Olek, Elliot Frohman

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Although substantial capabilities have emerged in the ability to globally manage patients who have MS, clinicians continue to be confronted with formidable challenges. Reduction in disease activity and its impact on disability progression remains the central objective of disease-modifying therapy and most current MS research initiatives. Nevertheless, the principal factors that determine the day-to-day limitations on functional capabilities (activities of daily living, work performance, quality of life, and so forth) are a derivative of the pathophysiology of the disease process itself. The substrate for these limitations is inherent in the pathology of demyelination and axonal dysfunction. Identifying measures that can optimize the performance and fidelity of axonal conduction mechanisms may translate into a reduction in MS-related symptoms. Chronic neurologic disease management (with MS representing a signature example) can be optimized when all members of the care team (including patients and their families) collaborate in the coordination of interdisciplinary care models that address all aspects of suffering.

Original languageEnglish (US)
Pages (from-to)199-214
Number of pages16
JournalNeurologic Clinics
Issue number2
StatePublished - May 2006

ASJC Scopus subject areas

  • Clinical Neurology


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