Development of cholinergic neurons in the septal/diagonal band complex of the rat

David M. Armstrong; Gordon Bruce; Louis B. Hersh; Fred H. Gage

doi:10.1016/0165-3806(87)90028-9

Development of cholinergic neurons in the septal/diagonal band complex of the rat

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Fred H. Gage

Pediatrics

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Abstract

In the present study we employed immunohistochemical techniques using a polyclonal antibody against choline acetyltransferase (ChAT) to determine the distribution and cytological features of cholinergic neurons in the developing septal/diagonal band complex of the rat. ChAT-positive perikarya were first clearly detected in this region on embryonic day 17, although the neurons were faintly labeled and lacked the cytological details found in the adult. After birth we observed a dramatic increase in the intensity of the immunolabeling which continued until postnatal day 23. Thereafter, the ChAT-positive neurons assumed their adult-like characteristics.

Original language	English (US)
Pages (from-to)	249-256
Number of pages	8
Journal	Developmental Brain Research
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(87)90028-9
State	Published - Dec 1 1987

Keywords

Choline acetyltransferase
Development
Immunocytochemistry
Rat
Septal/diagonal band

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(87)90028-9

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abstract = "In the present study we employed immunohistochemical techniques using a polyclonal antibody against choline acetyltransferase (ChAT) to determine the distribution and cytological features of cholinergic neurons in the developing septal/diagonal band complex of the rat. ChAT-positive perikarya were first clearly detected in this region on embryonic day 17, although the neurons were faintly labeled and lacked the cytological details found in the adult. After birth we observed a dramatic increase in the intensity of the immunolabeling which continued until postnatal day 23. Thereafter, the ChAT-positive neurons assumed their adult-like characteristics.",

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AU - Hersh, Louis B.

AU - Gage, Fred H.

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AB - In the present study we employed immunohistochemical techniques using a polyclonal antibody against choline acetyltransferase (ChAT) to determine the distribution and cytological features of cholinergic neurons in the developing septal/diagonal band complex of the rat. ChAT-positive perikarya were first clearly detected in this region on embryonic day 17, although the neurons were faintly labeled and lacked the cytological details found in the adult. After birth we observed a dramatic increase in the intensity of the immunolabeling which continued until postnatal day 23. Thereafter, the ChAT-positive neurons assumed their adult-like characteristics.

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KW - Development

KW - Immunocytochemistry

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KW - Septal/diagonal band

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Development of cholinergic neurons in the septal/diagonal band complex of the rat

Abstract

Keywords

ASJC Scopus subject areas

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