Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Jacinth Naidoo; Christopher J. Bemben; Shawn R. Allwein; Jue Liang; Andrew A. Pieper; Joseph M. Ready

doi:10.1016/j.tetlet.2013.06.024

Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Jacinth Naidoo, Christopher J. Bemben, Shawn R. Allwein, Jue Liang, Andrew A. Pieper, Joseph M. Ready

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.

Original language	English (US)
Pages (from-to)	4429-4431
Number of pages	3
Journal	Tetrahedron Letters
Volume	54
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2013.06.024
State	Published - Aug 14 2013

Keywords

Carbazole
Fluorination
Neuroprotective
Synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2013.06.024

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title = "Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent",

abstract = "A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.",

keywords = "Carbazole, Fluorination, Neuroprotective, Synthesis",

author = "Jacinth Naidoo and Bemben, {Christopher J.} and Allwein, {Shawn R.} and Jue Liang and Pieper, {Andrew A.} and Ready, {Joseph M.}",

note = "Funding Information: This work was supported by the Edward N. and Della C. Thome Memorial Foundation and the Welch Foundation ( I-1612 ) (to J.M.R). Additional support was received from The Hartwell Foundation and NIH ( NIMH R01 MH087986 ) to A.A.P. ",

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T1 - Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

AU - Naidoo, Jacinth

AU - Bemben, Christopher J.

AU - Allwein, Shawn R.

AU - Liang, Jue

AU - Pieper, Andrew A.

AU - Ready, Joseph M.

N1 - Funding Information: This work was supported by the Edward N. and Della C. Thome Memorial Foundation and the Welch Foundation ( I-1612 ) (to J.M.R). Additional support was received from The Hartwell Foundation and NIH ( NIMH R01 MH087986 ) to A.A.P.

PY - 2013/8/14

Y1 - 2013/8/14

N2 - A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.

AB - A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.

KW - Carbazole

KW - Fluorination

KW - Neuroprotective

KW - Synthesis

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Abstract

Keywords

ASJC Scopus subject areas

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