TY - GEN
T1 - Development and Evaluation of a PET Dedicated for On-line Imaging and Proton Beam-Range Measurement
AU - Yang, Dongxu
AU - Cheng, Xinyi
AU - Shao, Yiping
N1 - Funding Information:
Manuscript received December 1, 2021. This work was supported by the National Institutes of Health under Grant No. 1R01CA218402, 1R01EB019438, and R21 CA187717 Dongxu Yang, Xinyi Cheng and Yiping Shao are with the Department of Radiation Oncology of The University of Texas Southwestern Medical Center, Dallas, TX 75390 USA (telephone: 214-645-1274, e-mail: yiping.shao@southwestern.edu).
Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - A prototype human brain PET dedicated for proton on-line imaging and beam range measurement has been developed and tested with point sources. The PET can be configured in either a closed gantry or open gantry configuration to allow either a full-ring tomographic imaging or a two half-ring imaging for allowing beam passing through the scanner for radiation. Advanced large size (65×65×30 mm3) planar detector and readout electronics with multiplex reduced readout channels were applied. The measured mean energy and coincidence timing resolutions (at the detector level) are ~27.2% and 9.4 ns after corrections. The PET can provide an 18 cm diameter and 6.5 cm axial field of view for proton beam imaging and range measurement. The measured spatial resolution is around ~3 mm uniformly within 6 to 8 cm diameter FOV, and the difference between the acquisitions with closed or open gantry PET configuration is <1.0 mm along the expected beam path over 18 cm length. In summary, the brain PET has been developed and evaluated with sufficient imaging performance for the next on-line imaging. The proton beam range measurement with on-line imaging is under investigation with a new PET gantry and mobile mechanical supporting cart at a clinical proton therapy facility.
AB - A prototype human brain PET dedicated for proton on-line imaging and beam range measurement has been developed and tested with point sources. The PET can be configured in either a closed gantry or open gantry configuration to allow either a full-ring tomographic imaging or a two half-ring imaging for allowing beam passing through the scanner for radiation. Advanced large size (65×65×30 mm3) planar detector and readout electronics with multiplex reduced readout channels were applied. The measured mean energy and coincidence timing resolutions (at the detector level) are ~27.2% and 9.4 ns after corrections. The PET can provide an 18 cm diameter and 6.5 cm axial field of view for proton beam imaging and range measurement. The measured spatial resolution is around ~3 mm uniformly within 6 to 8 cm diameter FOV, and the difference between the acquisitions with closed or open gantry PET configuration is <1.0 mm along the expected beam path over 18 cm length. In summary, the brain PET has been developed and evaluated with sufficient imaging performance for the next on-line imaging. The proton beam range measurement with on-line imaging is under investigation with a new PET gantry and mobile mechanical supporting cart at a clinical proton therapy facility.
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U2 - 10.1109/NSS/MIC44867.2021.9875721
DO - 10.1109/NSS/MIC44867.2021.9875721
M3 - Conference contribution
AN - SCOPUS:85139158025
T3 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
BT - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
A2 - Tomita, Hideki
A2 - Nakamura, Tatsuya
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Y2 - 16 October 2021 through 23 October 2021
ER -