Developing a tablet-based self-persuasion intervention promotin adolescent hpv vaccination: Protocol for a three-stag mixed-methods study

Jasmin A. Tiro, Simon Craddock Lee, Emily G. Marks, Donna Persaud, Celette Sugg Skinner, Richard L. Street, Deborah J. Wiebe, David Farrell, Wendy Pechero Bishop, Sobha Fuller, Austin S. Baldwin

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Human papillomavirus (HPV)-related cancers are a significant burden on the US health care system that can bprevented through adolescent HPV vaccination. Despite guidelines recommending vaccination, coverage among US adolescentis suboptimal particularly among underserved patients (uninsured, low income, racial, and ethnic minorities) seen in safety-nehealth care settings. Many parents are ambivalent about the vaccine and delay making a decision or talking with a provider abouit. Self-persuasion generating one s own arguments for a health behavior may be particularly effective for parents who arundecided or not motivated to make a vaccine decision Objective: Through a 3-stage mixed-methods protocol, we will identify an optimal and feasible self-persuasion interventiostrategy to promote adolescent HPV vaccination in safety-net clinics Methods: In Stage 1, we will define content for a tablet-based self-persuasion app by characterizing (1) parents self-generatearguments through cognitive interviews conducted with parents (n=50) of patients and (2) parent-provider HPV vaccine discussionthrough audio recordings of clinic visits (n=50). In Stage 2, we will compare the effects of the four self-persuasion interventioconditions that vary by cognitive processing level (parents verbalize vs listen to arguments) and choice of argument topics (parentchoose vs are assigned topics) on parental vaccine intentions in a 2 × 2 factorial design randomized controlled trial (n=160). Thiproof-of-concept trial design will identify which intervention condition is optimal by quantitatively examining basic self-persuasiomechanisms (cognitive processing and choice) and qualitatively exploring parent experiences with intervention tasks. In Stag3, we will conduct a pilot trial (n=90) in the safety-net clinics to assess feasibility of the optimal intervention condition identifiein Stage 2. We will also assess its impact on parent-provider discussions Results: This paper describes the study protocol and activities to date. Currently, we have developed the initial prototype of thtablet app for English-and Spanish-speaking populations, and completed Stage 1 data collection Conclusions: Our systematic collaboration between basic and applied behavioral scientists accelerates translation of promisinbasic psychological research into innovative interventions suitable for underserved, safety-net populations. At project s end, wplan to have a feasible and acceptable self-persuasion intervention that can affect key cancer disparities in the United Statethrough prevention of HPV-related cancers Trial Registration: an (Archived by WebCite at an, respectively).

Original languageEnglish (US)
Article number5092
JournalJMIR Research Protocols
Issue number1
StatePublished - Jan 2016


  • HPV vaccination
  • adolescents
  • intervention development
  • self-persuasion

ASJC Scopus subject areas

  • Medicine(all)


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