Deuterium nuclear magnetic resonance spin-imaging of D2O: A potential exogenous MRI label

Coleen S. Ewy; Evelyn E. Babcock; Joseph J H Ackerman

doi:10.1016/0730-725X(86)90047-0

Deuterium nuclear magnetic resonance spin-imaging of D₂O: A potential exogenous MRI label

Coleen S. Ewy, Evelyn E. Babcock, Joseph J H Ackerman

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Recent development of high-field wide-bore magnets for spin-imaging applications has made feasible the observation of nuclear spins of low sensitivity. We propose the in vivo use of deuterium, specifically D₂O, as an exogeneous magnetic resonance nuclear spin label of clinically significant potential. The combination of an efficient quadrupole relaxation mechanism, low acute toxicity and ready commercial availability of D₂O for in situ enrichment will provide sufficient sensitivity for magnetic resonance imaging.

Original language	English (US)
Pages (from-to)	407-411
Number of pages	5
Journal	Magnetic Resonance Imaging
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/0730-725X(86)90047-0
State	Published - 1986

Keywords

Contrast
DO
Deuterium
Flow
Heart
Rabbit

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/0730-725X(86)90047-0

Cite this

@article{56acee3bffdc4740a2a36b02e0e09116,

title = "Deuterium nuclear magnetic resonance spin-imaging of D2O: A potential exogenous MRI label",

abstract = "Recent development of high-field wide-bore magnets for spin-imaging applications has made feasible the observation of nuclear spins of low sensitivity. We propose the in vivo use of deuterium, specifically D2O, as an exogeneous magnetic resonance nuclear spin label of clinically significant potential. The combination of an efficient quadrupole relaxation mechanism, low acute toxicity and ready commercial availability of D2O for in situ enrichment will provide sufficient sensitivity for magnetic resonance imaging.",

keywords = "Contrast, DO, Deuterium, Flow, Heart, Rabbit",

author = "Ewy, {Coleen S.} and Babcock, {Evelyn E.} and Ackerman, {Joseph J H}",

note = "Funding Information: was supported by NIH grant GM 30331 and a gift from Mallinckrodt Inc.",

year = "1986",

doi = "10.1016/0730-725X(86)90047-0",

language = "English (US)",

volume = "4",

pages = "407--411",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Deuterium nuclear magnetic resonance spin-imaging of D2O

T2 - A potential exogenous MRI label

AU - Ewy, Coleen S.

AU - Babcock, Evelyn E.

AU - Ackerman, Joseph J H

N1 - Funding Information: was supported by NIH grant GM 30331 and a gift from Mallinckrodt Inc.

PY - 1986

Y1 - 1986

N2 - Recent development of high-field wide-bore magnets for spin-imaging applications has made feasible the observation of nuclear spins of low sensitivity. We propose the in vivo use of deuterium, specifically D2O, as an exogeneous magnetic resonance nuclear spin label of clinically significant potential. The combination of an efficient quadrupole relaxation mechanism, low acute toxicity and ready commercial availability of D2O for in situ enrichment will provide sufficient sensitivity for magnetic resonance imaging.

AB - Recent development of high-field wide-bore magnets for spin-imaging applications has made feasible the observation of nuclear spins of low sensitivity. We propose the in vivo use of deuterium, specifically D2O, as an exogeneous magnetic resonance nuclear spin label of clinically significant potential. The combination of an efficient quadrupole relaxation mechanism, low acute toxicity and ready commercial availability of D2O for in situ enrichment will provide sufficient sensitivity for magnetic resonance imaging.

KW - Contrast

KW - DO

KW - Deuterium

KW - Flow

KW - Heart

KW - Rabbit

UR - http://www.scopus.com/inward/record.url?scp=0023035952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023035952&partnerID=8YFLogxK

U2 - 10.1016/0730-725X(86)90047-0

DO - 10.1016/0730-725X(86)90047-0

M3 - Article

AN - SCOPUS:0023035952

SN - 0730-725X

VL - 4

SP - 407

EP - 411

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 5

ER -