Determining gentamicin dosage in infants and children with renal failure

Sayomporn Sirinavin, George H. McCracken, John D. Nelson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Gentamicin half-life values based on pharmacologic calculations were determined in 23 infants and children with diminished renal function. The half-life times correlated significantly with serum creatinine concentrations in patients who had steady-state creatinine levels (Y=0.379+3.841X, R=0.951, P<0.001). This relationship provides a basis for formulating gentamicin dosage in pediatric patients with renal failure. The half-life of gentamicin is estimated by multiplying the serum creatinine concentration by four; three-quarters of the loading dose is administered every two half-lives. When renal function is unstable and changing daily, gentamicin half-life cannot be reliably predicted from the serum creatinine value.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalThe Journal of pediatrics
Issue number2
StatePublished - Feb 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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