TY - JOUR
T1 - Determining gentamicin dosage in infants and children with renal failure
AU - Sirinavin, Sayomporn
AU - McCracken, George H.
AU - Nelson, John D.
N1 - Funding Information:
From the Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School. Supported by a grant from the John A. Hartford Foundation, Incorporated. *Reprint address: Department of Pediatrics, University of. Texas Health Science Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235
PY - 1980/2
Y1 - 1980/2
N2 - Gentamicin half-life values based on pharmacologic calculations were determined in 23 infants and children with diminished renal function. The half-life times correlated significantly with serum creatinine concentrations in patients who had steady-state creatinine levels (Y=0.379+3.841X, R=0.951, P<0.001). This relationship provides a basis for formulating gentamicin dosage in pediatric patients with renal failure. The half-life of gentamicin is estimated by multiplying the serum creatinine concentration by four; three-quarters of the loading dose is administered every two half-lives. When renal function is unstable and changing daily, gentamicin half-life cannot be reliably predicted from the serum creatinine value.
AB - Gentamicin half-life values based on pharmacologic calculations were determined in 23 infants and children with diminished renal function. The half-life times correlated significantly with serum creatinine concentrations in patients who had steady-state creatinine levels (Y=0.379+3.841X, R=0.951, P<0.001). This relationship provides a basis for formulating gentamicin dosage in pediatric patients with renal failure. The half-life of gentamicin is estimated by multiplying the serum creatinine concentration by four; three-quarters of the loading dose is administered every two half-lives. When renal function is unstable and changing daily, gentamicin half-life cannot be reliably predicted from the serum creatinine value.
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U2 - 10.1016/S0022-3476(80)80841-9
DO - 10.1016/S0022-3476(80)80841-9
M3 - Article
C2 - 7351608
AN - SCOPUS:0018873650
SN - 0022-3476
VL - 96
SP - 331
EP - 334
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 2
ER -