TY - JOUR
T1 - Detection of Carotid Artery Stenosis with Intraplaque Hemorrhage and Neovascularization Using a Scanning Interferometer
AU - Zaman, Raiyan Tripti
AU - Kosuge, Hisanori
AU - Gambhir, Sanjiv Sam
AU - Xing, Lei
N1 - Funding Information:
The authors of this manuscripts are grateful to Dr. Timothy Doyle for letting Dr. Zaman setup the system in the Small Animal (SCI) Imaging Center at the Stanford University School of Medicine. This study was partly support by the American Heart Association Postdoctoral Fellowship (AHA 13POST17290051). This funding agency has no influence on the experimental design and data analysis. 3
Publisher Copyright:
© 2021 American Chemical Society
PY - 2021/7/14
Y1 - 2021/7/14
N2 - Carotid artery stenosis (CAS) is a major cause of stroke or transient ischemic attack (TIA, mini-stroke) in the United States. Carotid endarterectomy (CEA), a surgical procedure, is used to treat CAS. According to the American Heart Association, 1 out of 5 patients underwent CEA inappropriately, which was most commonly due to apparent overestimation of stenosis severity, and half had uncertain indicators. The current imaging modalities are limited in providing critical information on carotid arterial plaque content, extent, and biology. To circumvent these limitations, we developed a sensing interferometer (SI) imaging system to assess vulnerable carotid plaques noninvasively to detect stenosis, neovascularization, and intraplaque hemorrhage (IPH). We have custom-built a SI prototype and its peripheral systems with back-mode-projection capability. We detected stenosis, neo-vessels, and IPH through SI imaging system in in vivo mice carotid atherosclerotic plaques and further verified the same plaques ex vivo through a histology scope, CRi Maestro, and histological analysis.
AB - Carotid artery stenosis (CAS) is a major cause of stroke or transient ischemic attack (TIA, mini-stroke) in the United States. Carotid endarterectomy (CEA), a surgical procedure, is used to treat CAS. According to the American Heart Association, 1 out of 5 patients underwent CEA inappropriately, which was most commonly due to apparent overestimation of stenosis severity, and half had uncertain indicators. The current imaging modalities are limited in providing critical information on carotid arterial plaque content, extent, and biology. To circumvent these limitations, we developed a sensing interferometer (SI) imaging system to assess vulnerable carotid plaques noninvasively to detect stenosis, neovascularization, and intraplaque hemorrhage (IPH). We have custom-built a SI prototype and its peripheral systems with back-mode-projection capability. We detected stenosis, neo-vessels, and IPH through SI imaging system in in vivo mice carotid atherosclerotic plaques and further verified the same plaques ex vivo through a histology scope, CRi Maestro, and histological analysis.
KW - back-mode-projection
KW - carotid arterial stenosis
KW - intraplaque hemorrhage
KW - neovascularization
KW - scanning interferometer
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U2 - 10.1021/acs.nanolett.1c01441
DO - 10.1021/acs.nanolett.1c01441
M3 - Article
C2 - 34156253
AN - SCOPUS:85110255669
SN - 1530-6984
VL - 21
SP - 5714
EP - 5721
JO - Nano Letters
JF - Nano Letters
IS - 13
ER -