@article{63dbbe29199b4b5fb647b99ffab0b50d,
title = "Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice",
abstract = "Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to as dWAT) has been the focus of much discussion in recent years. However, dWAT remains poorly characterized. The fate of the mature dermal adipocytes and the origin of the rapidly reappearing dermal adipocytes at different stages remain unclear. Here, we isolated dermal adipocytes and characterized dermal fat at the cellular and molecular level. Together with dWAT's dynamic responses to external stimuli, we established that dermal adipocytes are a distinct class of white adipocytes with high plasticity. By combining pulse-chase lineage tracing and single-cell RNA sequencing, we observed that mature dermal adipocytes undergo dedifferentiation and redifferentiation under physiological and pathophysiological conditions. Upon various challenges, the dedifferentiated cells proliferate and redifferentiate into adipocytes. In addition, manipulation of dWAT highlighted an important role for mature dermal adipocytes for hair cycling and wound healing. Altogether, these observations unravel a surprising plasticity of dermal adipocytes and provide an explanation for the dynamic changes in dWAT mass that occur under physiological and pathophysiological conditions, and highlight the important contributions of dWAT toward maintaining skin homeostasis.",
author = "Zhuzhen Zhang and Mengle Shao and Chelsea Hepler and Zhenzhen Zi and Shangang Zhao and An, {Yu A.} and Yi Zhu and Ghaben, {Alexandra L.} and Wang May-Yun and Na Li and Toshiharu Onodera and Nolwenn Joffin and Clair Crewe and Qingzhang Zhu and Lavanya Vishvanath and Ashwani Kumar and Chao Xing and Wang, {Qiong A.} and Laurent Gautron and Yingfeng Deng and Ruth Gordillo and Ilja Kruglikov and Kusminski, {Christine M.} and Gupta, {Rana K.} and Scherer, {Philipp E.}",
note = "Funding Information: We thank all the members of the Scherer and Gupta laboratories for their support of this study. We also thank the University of Texas Southwestern Medical Center Metabolic Core Facility, McDermott Center Next Generation Sequencing Core and Bioinformatics Lab, Flow Cytometry Core of the Children{\textquoteright}s Research Institute, Histopathology Core, Live Cell Imaging Core, and Animal Resource Center; as well as Charlotte Lee for help with histology. This study was supported by American Heart Association Postdoctoral Award 16POST26420136 and Career Development Award 19CDA34670007 from the American Heart Association and the Harry S. Moss Heart Trust to MS; and NIH grants R01-DK104789, R56-DK119163, and R01-DK119163 to RKG; RC2-DK118620 to PES and RKG; and R01-DK55758, R01-DK099110, P01-DK088761, and P01-AG051459 to PES. PES was also supported by an unrestricted research grant from the Novo Nordisk Foundation. Funding Information: We thank all the members of the Scherer and Gupta laboratories for their support of this study. We also thank the University of Texas Southwestern Medical Center Metabolic Core Facility, McDermott Center Next Generation Sequencing Core and Bioinformatics Lab, Flow Cytometry Core of the Children's Research Institute, Histopathology Core, Live Cell Imaging Core, and Animal Resource Center; as well as Charlotte Lee for help with histology. This study was supported by American Heart Association Postdoctoral Award 16POST26420136 and Career Development Award 19CDA34670007 from the American Heart Association and the Harry S. Moss Heart Trust to MS; and NIH grants R01-DK104789, R56-DK119163, and R01-DK119163 to RKG; RC2-DK118620 to PES and RKG; and R01-DK55758, R01-DK099110, P01-DK088761, and P01-AG051459 to PES. PES was also supported by an unrestricted research grant from the Novo Nordisk Foundation. Publisher Copyright: Copyright: {\textcopyright} 2019, American Society for Clinical Investigation.",
year = "2019",
month = dec,
day = "2",
doi = "10.1172/JCI130239",
language = "English (US)",
volume = "129",
pages = "5327--5342",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "12",
}