TY - JOUR
T1 - Depression and hippocampal neurogenesis
T2 - A road to remission?
AU - Eisch, Amelia J.
AU - Petrik, David
PY - 2012/10/5
Y1 - 2012/10/5
N2 - Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research - involving stress, depression, and neurogenesis - highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the "neurogenic interactome," a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives-system, region, and local regulation of neurogenesis - offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.
AB - Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research - involving stress, depression, and neurogenesis - highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the "neurogenic interactome," a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives-system, region, and local regulation of neurogenesis - offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.
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U2 - 10.1126/science.1222941
DO - 10.1126/science.1222941
M3 - Review article
C2 - 23042885
AN - SCOPUS:84867213664
SN - 0036-8075
VL - 338
SP - 72
EP - 75
JO - Science
JF - Science
IS - 6103
ER -