@article{725dc8a2d5e04ddb83e6a1b0a9791fd8,
title = "Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains",
abstract = "Background: Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. Objectives: To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Methods: Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Results: Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Conclusions: Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.",
keywords = "essential tremor; cerebellum; dentate neuron; stereology; pathology",
author = "Hartstone, {Whitney G.} and Brown, {Mark H.} and Kelly, {Geoffrey C.} and Tate, {William J.} and Kuo, {Sheng Han} and Dwork, {Andrew J.} and Louis, {Elan D.} and Faust, {Phyllis L.}",
note = "Funding Information: This work was supported by the National Institutes of Health (NINDS R01 NS088257). Funding Information: S.H.K. has received funding from the National Institutes of Health: NINDS R01 NS104423 (principal investigator), NINDS R03 NS114871 (principal investigator), the Louis V. Gerstner Jr. Scholar Award, Parkinson's Foundation, and International Essential Tremor Foundation. A.J.D. has received funding from the National Institutes of Health: NIMH/FIC 1R56 MH117769 (principal investigator) and NIA R01AG066162 (co‐investigator), Lyme Disease Biobank Foundation (principal investigator), the US Veterans Affairs: 1I01BX003794, and 5I01BX002876 (co‐investigator on both). E.D.L. has received research support from the National Institutes of Health: NINDS R01 NS094607 (principal investigator), NINDS R01 NS085136 (principal investigator), NINDS R01 NS073872 (principal investigator), and NINDS R01 NS088257 (principal investigator). He has also received support from the Claire O'Neil Essential Tremor Research Fund (Yale University). P.L.F. has received funding from the National Institutes of Health: NINDS R01 NS085136 (principal investigator), NINDS RO1 NS088257 (principal investigator), and NINDS R01 NS086736 (co‐investigator). Publisher Copyright: {\textcopyright} 2020 International Parkinson and Movement Disorder Society",
year = "2021",
month = apr,
doi = "10.1002/mds.28402",
language = "English (US)",
volume = "36",
pages = "995--999",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "4",
}