Demarcated glioblastoma multiforme and prolonged angiographic tumor stain

We have encountered four pathologically verified glioblastomas, all of which on angiography were associated with a prolonged tumor stain. In one case the neoplasm was mistaken for a meningioma by the neurosurgeon and in two others the surgeon's impression was that of a well demarcated lesion. Tissue from the fourth case removed en bloc permitted a satisfactory neuropathological examination which demonstrated good demarcation. - This observation of the association of demarcation and persistence of tumor stain, although by no means a pathognomonic sign, should alert one's attention to the possibility of more radical resection in glioblastoma surgery.