Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Dedee F. Murrell; Branka Marinovic; Frederic Caux; Catherine Prost; Razzaque Ahmed; Katarzyna Wozniak; Masayuki Amagai; Johann Bauer; Stefan Beissert; Luca Borradori; Donna Culton; Janet A. Fairley; David Fivenson; Marcel F. Jonkman; M. Peter Marinkovich; David Woodley; John Zone; Valeria Aoki; Philippe Bernard; Leen Bruckner-Tuderman; Giuseppe Cianchini; Vanessa Venning; Luis Diaz; Rudiger Eming; Sergei A. Grando; Russell P. Hall; Takashi Hashimoto; Josep E. Herrero-González; Michael Hertl; Pascal Joly; Sarolta Karpati; Jaehwan Kim; Soo Chan Kim; Neil J. Korman; Cezary Kowalewski; Sang Eun Lee; David R. Rubenstein; Eli Sprecher; Kim Yancey; Giovann Zambruno; Detlef Zillikens; Serge Doan; Benjamin S. Daniel; Victoria P. Werth

doi:10.1016/j.jaad.2014.08.024

Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Dedee F. Murrell, Branka Marinovic, Frederic Caux, Catherine Prost, Razzaque Ahmed, Katarzyna Wozniak, Masayuki Amagai, Johann Bauer, Stefan Beissert, Luca Borradori, Donna Culton, Janet A. Fairley, David Fivenson, Marcel F. Jonkman, M. Peter Marinkovich, David Woodley, John Zone, Valeria Aoki, Philippe Bernard, Leen Bruckner-TudermanGiuseppe Cianchini, Vanessa Venning, Luis Diaz, Rudiger Eming, Sergei A. Grando, Russell P. Hall, Takashi Hashimoto, Josep E. Herrero-González, Michael Hertl, Pascal Joly, Sarolta Karpati, Jaehwan Kim, Soo Chan Kim, Neil J. Korman, Cezary Kowalewski, Sang Eun Lee, David R. Rubenstein, Eli Sprecher, Kim Yancey, Giovann Zambruno, Detlef Zillikens, Serge Doan, Benjamin S. Daniel, Victoria P. Werth

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Abstract

Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.

Original language	English (US)
Pages (from-to)	168-174
Number of pages	7
Journal	Journal of the American Academy of Dermatology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1016/j.jaad.2014.08.024
State	Published - Jan 1 2015

Keywords

consensus
definitions
mucous membrane pemphigoid
outcome measures
severity score

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2014.08.024

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Murrell, D. F., Marinovic, B., Caux, F., Prost, C., Ahmed, R., Wozniak, K., Amagai, M., Bauer, J., Beissert, S., Borradori, L., Culton, D., Fairley, J. A., Fivenson, D., Jonkman, M. F., Marinkovich, M. P., Woodley, D., Zone, J., Aoki, V., Bernard, P., ... Werth, V. P. (2015). Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts. Journal of the American Academy of Dermatology, 72(1), 168-174. https://doi.org/10.1016/j.jaad.2014.08.024

Murrell, DF, Marinovic, B, Caux, F, Prost, C, Ahmed, R, Wozniak, K, Amagai, M, Bauer, J, Beissert, S, Borradori, L, Culton, D, Fairley, JA, Fivenson, D, Jonkman, MF, Marinkovich, MP, Woodley, D, Zone, J, Aoki, V, Bernard, P, Bruckner-Tuderman, L, Cianchini, G, Venning, V, Diaz, L, Eming, R, Grando, SA, Hall, RP, Hashimoto, T, Herrero-González, JE, Hertl, M, Joly, P, Karpati, S, Kim, J, Chan Kim, S, Korman, NJ, Kowalewski, C, Lee, SE, Rubenstein, DR, Sprecher, E, Yancey, K, Zambruno, G, Zillikens, D, Doan, S, Daniel, BS & Werth, VP 2015, 'Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts', Journal of the American Academy of Dermatology, vol. 72, no. 1, pp. 168-174. https://doi.org/10.1016/j.jaad.2014.08.024

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abstract = "Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.",

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AU - Caux, Frederic

AU - Prost, Catherine

AU - Ahmed, Razzaque

AU - Wozniak, Katarzyna

AU - Amagai, Masayuki

AU - Bauer, Johann

AU - Beissert, Stefan

AU - Borradori, Luca

AU - Culton, Donna

AU - Fairley, Janet A.

AU - Fivenson, David

AU - Jonkman, Marcel F.

AU - Marinkovich, M. Peter

AU - Woodley, David

AU - Zone, John

AU - Aoki, Valeria

AU - Bernard, Philippe

AU - Bruckner-Tuderman, Leen

AU - Cianchini, Giuseppe

AU - Venning, Vanessa

AU - Diaz, Luis

AU - Eming, Rudiger

AU - Grando, Sergei A.

AU - Hall, Russell P.

AU - Hashimoto, Takashi

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AU - Hertl, Michael

AU - Joly, Pascal

AU - Karpati, Sarolta

AU - Kim, Jaehwan

AU - Chan Kim, Soo

AU - Korman, Neil J.

AU - Kowalewski, Cezary

AU - Lee, Sang Eun

AU - Rubenstein, David R.

AU - Sprecher, Eli

AU - Yancey, Kim

AU - Zambruno, Giovann

AU - Zillikens, Detlef

AU - Doan, Serge

AU - Daniel, Benjamin S.

AU - Werth, Victoria P.

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AB - Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.

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Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Abstract

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