TY - JOUR
T1 - Defects of the otoconial membranes in normal Guinea pigs
AU - Johnsson, Lars Göran
AU - Wright, Charles G.
AU - Preston, Robert E.
AU - Henry, Pamela J.
N1 - Funding Information:
This investigation was supported by USPHS Grants NS 11672 and NS 12706 and Program Project Grant NS 05785 and by a grant from the Leland Fikes Foundation to the University of Texas at Dallas subcontracted through the Aberrant Behavior Center, Dallas, Texas.
PY - 1980
Y1 - 1980
N2 - Otoconial membranes from a large number of normal albino and pigmented guinea pigs were examined by light microscopy. In more than 20% of the animals, microdissection revealed that the crystalline layer of the otoconial membrane was incomplete, leaving large areas of the underlying gelatinous layer uncovered by crystals. These defects were bilateral, more or less symmetrical, and invariably more extensive in the saccule than in the utricle. In two animals, huge single conglomerates of crystals were found on both the saccular and utricular maculae. None of the animals displayed abnormal behavior or posture and no obvious cause for the otoconial defects was found. The presence of a hereditary congenital condition is postulated. The high incidence of otoconial defects in guinea pigs makes them poorly suited for most investigations of experimentally induced pathology. Therefore, previous reports of otoconial pathology in guinea pigs should be viewed in the light of these findings.
AB - Otoconial membranes from a large number of normal albino and pigmented guinea pigs were examined by light microscopy. In more than 20% of the animals, microdissection revealed that the crystalline layer of the otoconial membrane was incomplete, leaving large areas of the underlying gelatinous layer uncovered by crystals. These defects were bilateral, more or less symmetrical, and invariably more extensive in the saccule than in the utricle. In two animals, huge single conglomerates of crystals were found on both the saccular and utricular maculae. None of the animals displayed abnormal behavior or posture and no obvious cause for the otoconial defects was found. The presence of a hereditary congenital condition is postulated. The high incidence of otoconial defects in guinea pigs makes them poorly suited for most investigations of experimentally induced pathology. Therefore, previous reports of otoconial pathology in guinea pigs should be viewed in the light of these findings.
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U2 - 10.3109/00016488009127114
DO - 10.3109/00016488009127114
M3 - Article
C2 - 6105757
AN - SCOPUS:0018904930
SN - 0001-6489
VL - 89
SP - 93
EP - 104
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 1-2
ER -