TY - JOUR
T1 - Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
AU - Westermeier, Francisco
AU - Navarro-Marquez, Mario
AU - López-Crisosto, Camila
AU - Bravo-Sagua, Roberto
AU - Quiroga, Clara
AU - Bustamante, Mario
AU - Verdejo, Hugo E.
AU - Zalaquett, Ricardo
AU - Ibacache, Mauricio
AU - Parra, Valentina
AU - Castro, Pablo F.
AU - Rothermel, Beverly A
AU - Hill, Joseph A
AU - Lavandero, Sergio
N1 - Funding Information:
This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT) , Chile: FONDAP 15130011 (SL), FONDECYT 1120212 (SL), FONDECYT 3140532 (FW), National Institutes of Health ( HL-120732 to J.A.H.; HL100401 to J.A.H.; HL097768 to B.A.R.; HL072016 to B.A.R.), American Heart Association ( 14SFRN20740000 ) (Prevention Network to J.A.H.), CPRIT ( RP110486P3 to J.A.H.), the Leducq Foundation ( 11CVD04 to J.A.H.). V.P. thanks the American Heart Association ( 13POST16520009 ) for Postdoctoral Funding.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart. Myocardial energy metabolism depends on mitochondria, which must generate sufficient ATP to meet the high energy demands of the myocardium. Dysfunctional mitochondria are involved in the pathophysiology of diabetic heart disease. A large body of evidence implicates myocardial insulin resistance in the pathogenesis of DCM. Recent studies show that insulin signaling influences myocardial energy metabolism by impacting cardiomyocyte mitochondrial dynamics and function under physiological conditions. However, comprehensive understanding of molecular mechanisms linking insulin signaling and changes in the architecture of the mitochondrial network in diabetic cardiomyopathy is lacking. This review summarizes our current understanding of how defective insulin signaling impacts cardiac function in diabetic cardiomyopathy and discusses the potential role of mitochondrial dynamics.
AB - Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart. Myocardial energy metabolism depends on mitochondria, which must generate sufficient ATP to meet the high energy demands of the myocardium. Dysfunctional mitochondria are involved in the pathophysiology of diabetic heart disease. A large body of evidence implicates myocardial insulin resistance in the pathogenesis of DCM. Recent studies show that insulin signaling influences myocardial energy metabolism by impacting cardiomyocyte mitochondrial dynamics and function under physiological conditions. However, comprehensive understanding of molecular mechanisms linking insulin signaling and changes in the architecture of the mitochondrial network in diabetic cardiomyopathy is lacking. This review summarizes our current understanding of how defective insulin signaling impacts cardiac function in diabetic cardiomyopathy and discusses the potential role of mitochondrial dynamics.
KW - Diabetic cardiomyopathy
KW - Insulin signaling
KW - Mitochondrial dynamics
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U2 - 10.1016/j.bbamcr.2015.02.005
DO - 10.1016/j.bbamcr.2015.02.005
M3 - Review article
C2 - 25686534
AN - SCOPUS:84923602928
SN - 0167-4889
VL - 1853
SP - 1113
EP - 1118
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 5
ER -