TY - CHAP
T1 - Deep brain stimulation for dystonia
AU - Suescun, Jessika
AU - Furr-Stimming, Erin
AU - Patel, Neepa
N1 - Funding Information:
E.R. and D.G. contributed equally to this chapter. The authors would like to thank their study funders, the APHP (Assistance Publique-Hôpitaux de Paris) and DRRC (Direction Régionale de la Recherche Clinique), and are grateful for the support of the patient associations, Alliance France Dystonie and Association des Malades Atteints de Dystonie (AMADYS). The research leading to these results received funding from the program “Investissements d’Avenir” (ANR-10-IAIHU-06).
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Dystonia is a heterogeneous movement disorder characterized by sustained or intermittent contraction of agonist and antagonist muscles producing abnormal postures. Dystonia can be focal, multifocal, segmental or generalized. Botulinum toxin injections are generally effective in treating focal dystonia. Oral medications can be effective in attenuating generalized and segmental dystonia, but have limitations. Generalized dystonia, however, is more often refractory to available medical therapies. Deep brain stimulation (DBS) has been established as an effective intervention to treat patients with dystonia refractory to medical therapy. This chapter describes the current accepted classification scheme for diagnosing dystonia, specific considerations for the phenomenology, etiology and treatment, and reviews the current literature evidence supporting the use of DBS in a variety of dystonia syndromes; it also provides general consideration for patient selection and recommendations for approach to programming DBS for the treatment of dystonia.
AB - Dystonia is a heterogeneous movement disorder characterized by sustained or intermittent contraction of agonist and antagonist muscles producing abnormal postures. Dystonia can be focal, multifocal, segmental or generalized. Botulinum toxin injections are generally effective in treating focal dystonia. Oral medications can be effective in attenuating generalized and segmental dystonia, but have limitations. Generalized dystonia, however, is more often refractory to available medical therapies. Deep brain stimulation (DBS) has been established as an effective intervention to treat patients with dystonia refractory to medical therapy. This chapter describes the current accepted classification scheme for diagnosing dystonia, specific considerations for the phenomenology, etiology and treatment, and reviews the current literature evidence supporting the use of DBS in a variety of dystonia syndromes; it also provides general consideration for patient selection and recommendations for approach to programming DBS for the treatment of dystonia.
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M3 - Chapter
AN - SCOPUS:84957707354
SN - 9781634832823
SP - 169
EP - 194
BT - Deep Brain Stimulation
PB - Nova Science Publishers, Inc.
ER -