@article{9eb0ce887cd248f58adeef093d1c94e1,
title = "Deep brain stimulation and climbing fiber synaptic pathology in essential tremor",
abstract = "Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461–465.",
author = "Kuo, {Sheng Han} and Lin, {Chi Ying} and Jie Wang and Liou, {Jyun You} and Pan, {Ming Kai} and Louis, {Ravi J.} and Wu, {Wei Pu} and Jesus Gutierrez and Louis, {Elan D.} and Faust, {Phyllis L.}",
note = "Funding Information: This work was supported by the NIH National Institute of Neurological Disorders and Stroke (K08 NS08738, S.-H.K. [principal investigator]; R01 NS042859 E.D.L. [principal investigator], P.L.F. [principal investigator]; R01 NS39422, E.D.L. [principal investigator]; R01 NS086736, E.D.L. [principal investigator]; R01 NS073872, E.D.L. [principal investigator]; R01 NS085136, E.D.L. [principal investigator], P.L.F. [principal investigator]; R01 NS088257, E.D.L. [principal investigator], P.L.F. [principal investigator]); Louis V. Gerstner Jr. Scholar Award (S.-H.K.); Parkinson's Disease Foundation (S.-H.K.); American Brain Foundation Research Fellowship (S.-H.K.); American Parkinson's Disease Association (S.-H.K.); International Essential Tremor Foundation (S.-H.K.); NIH National Institute of Environmental Health Sciences (pilot award ES009089, S.-H.K.); Smart Foundation (S.-H.K.); Jiangsu Government Scholarship for Overseas Studies (J.W.); Qing Lan Project supported by the Jiangsu Provincial Department of Education, China (J.W.); and Key Discipline Development Project of Jiangsu Province, China (JX10617801, J.W. [principal investigator]). We thank Dr A. H. Koeppen of the Veterans Affairs Medical Center, Albany, New York, who provided the rabbit polyclonal anti-VGluT2 antibody. Publisher Copyright: {\textcopyright} 2016 American Neurological Association",
year = "2016",
month = sep,
day = "1",
doi = "10.1002/ana.24728",
language = "English (US)",
volume = "80",
pages = "461--465",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",
}