Deep brain stimulation and climbing fiber synaptic pathology in essential tremor

Sheng Han Kuo; Chi Ying Lin; Jie Wang; Jyun You Liou; Ming Kai Pan; Ravi J. Louis; Wei Pu Wu; Jesus Gutierrez; Elan D. Louis; Phyllis L. Faust

doi:10.1002/ana.24728

Deep brain stimulation and climbing fiber synaptic pathology in essential tremor

Sheng Han Kuo, Chi Ying Lin, Jie Wang, Jyun You Liou, Ming Kai Pan, Ravi J. Louis, Wei Pu Wu, Jesus Gutierrez, Elan D. Louis, Phyllis L. Faust

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25 Scopus citations

Abstract

Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461–465.

Original language	English (US)
Pages (from-to)	461-465
Number of pages	5
Journal	Annals of Neurology
Volume	80
Issue number	3
DOIs	https://doi.org/10.1002/ana.24728
State	Published - Sep 1 2016
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Deep brain stimulation and climbing fiber synaptic pathology in essential tremor",

abstract = "Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461–465.",

author = "Kuo, {Sheng Han} and Lin, {Chi Ying} and Jie Wang and Liou, {Jyun You} and Pan, {Ming Kai} and Louis, {Ravi J.} and Wu, {Wei Pu} and Jesus Gutierrez and Louis, {Elan D.} and Faust, {Phyllis L.}",

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AU - Kuo, Sheng Han

AU - Lin, Chi Ying

AU - Wang, Jie

AU - Liou, Jyun You

AU - Pan, Ming Kai

AU - Louis, Ravi J.

AU - Wu, Wei Pu

AU - Gutierrez, Jesus

AU - Louis, Elan D.

AU - Faust, Phyllis L.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461–465.

AB - Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461–465.

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Deep brain stimulation and climbing fiber synaptic pathology in essential tremor

Abstract

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