Deep brain stimulation and climbing fiber synaptic pathology in essential tremor

Sheng Han Kuo, Chi Ying Lin, Jie Wang, Jyun You Liou, Ming Kai Pan, Ravi J. Louis, Wei Pu Wu, Jesus Gutierrez, Elan D. Louis, Phyllis L. Faust

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461–465.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
JournalAnnals of Neurology
Issue number3
StatePublished - Sep 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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