Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis

Carla García; Alejandra Soriano-Fallas; Juanita Lozano; Nora Leos; Ana M. Gomez; Octavio Ramilo; Asuncion Mejias

doi:10.1097/INF.0b013e31822dc8c1

Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis

Carla García, Alejandra Soriano-Fallas, Juanita Lozano, Nora Leos, Ana M. Gomez, Octavio Ramilo, Asuncion Mejias

Pediatrics

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The immunopathogenesis of respiratory syncytial virus (RSV) and human rhinovirus lower respiratory tract infections in children remains to be defined. We measured nasal wash concentrations of 29 cytokines in infants with RSV or human rhinovirus lower respiratory tract infections. Concentrations of interferon-γ in RSV and innate immunity cytokines in both infections inversely correlated with disease severity.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	31
Issue number	1
DOIs	https://doi.org/10.1097/INF.0b013e31822dc8c1
State	Published - Jan 2012

Keywords

Bronchiolitis
HRV
RSV
cytokines
disease severity
innate immunity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0b013e31822dc8c1

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AU - García, Carla

AU - Soriano-Fallas, Alejandra

AU - Lozano, Juanita

AU - Leos, Nora

AU - Gomez, Ana M.

AU - Ramilo, Octavio

AU - Mejias, Asuncion

PY - 2012/1

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AB - The immunopathogenesis of respiratory syncytial virus (RSV) and human rhinovirus lower respiratory tract infections in children remains to be defined. We measured nasal wash concentrations of 29 cytokines in infants with RSV or human rhinovirus lower respiratory tract infections. Concentrations of interferon-γ in RSV and innate immunity cytokines in both infections inversely correlated with disease severity.

KW - Bronchiolitis

KW - HRV

KW - RSV

KW - cytokines

KW - disease severity

KW - innate immunity

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Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis

Abstract

Keywords

ASJC Scopus subject areas

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