@article{71ec60ffd99641e896d488a8bd538834,
title = "Deciphering the role of lipid droplets in cardiovascular disease",
abstract = "Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.",
keywords = "Atherosclerosis, Heart failure, Metabolic syndrome, Obesity, Triglycerides",
author = "Goldberg, {Ira J.} and Karen Reue and Abumrad, {Nada A.} and Bickel, {Perry E.} and Sarah Cohen and Fisher, {Edward A.} and Galis, {Zorina S.} and Granneman, {James G.} and Lewandowski, {E. Douglas} and Robert Murphy and Michelle Olive and Schaffer, {Jean E.} and Lisa Schwartz-Longacre and Shulman, {Gerald I.} and Walther, {Tobias C.} and Jue Chen",
note = "Funding Information: This Workshop was supported by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH). Relevant grant supports of authors are as follows: Dr Abumrad: R01 DK033301, R01 DK060022, and R01 DK111175; Dr Cohen: NIH Intramural Program, National Institute of Child Health and Human Development; Dr Fisher: R01 HL127930, R01 HL084312, PO1 HL092969, and R01 HL129433; Dr Granneman: R01 DK 076629 and R01 DK105963; Dr Goldberg: R01 HL073029, R01 HL045095, PO1 HL092969, and R01 HL127649; Dr Lewandowski: R01 HL132525, R01 HL049244, and R01 HL113057; Dr Reue: P01 HL028481 and P01 HL090553; Dr Schaffer: R01 DK064989 and R01 DK108357; Dr Shulman: R01 DK113984, R01 DK40936, P30 DK045735, and the Howard Hughes Medical Institute; Dr Walther: R01 GM097194, the G. Harold and Leila Y. Mathers Foundation, and the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2018 American Heart Association, Inc.",
year = "2018",
doi = "10.1161/CIRCULATIONAHA.118.033704",
language = "English (US)",
volume = "138",
pages = "305--315",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}