Deciphering the role of lipid droplets in cardiovascular disease

Ira J. Goldberg; Karen Reue; Nada A. Abumrad; Perry E. Bickel; Sarah Cohen; Edward A. Fisher; Zorina S. Galis; James G. Granneman; E. Douglas Lewandowski; Robert Murphy; Michelle Olive; Jean E. Schaffer; Lisa Schwartz-Longacre; Gerald I. Shulman; Tobias C. Walther; Jue Chen

doi:10.1161/CIRCULATIONAHA.118.033704

Deciphering the role of lipid droplets in cardiovascular disease

Ira J. Goldberg, Karen Reue, Nada A. Abumrad, Perry E. Bickel, Sarah Cohen, Edward A. Fisher, Zorina S. Galis, James G. Granneman, E. Douglas Lewandowski, Robert Murphy, Michelle Olive, Jean E. Schaffer, Lisa Schwartz-Longacre, Gerald I. Shulman, Tobias C. Walther, Jue Chen

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.

Original language	English (US)
Pages (from-to)	305-315
Number of pages	11
Journal	Circulation
Volume	138
Issue number	3
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.118.033704
State	Published - 2018

Keywords

Atherosclerosis
Heart failure
Metabolic syndrome
Obesity
Triglycerides

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1161/CIRCULATIONAHA.118.033704

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Goldberg, I. J., Reue, K., Abumrad, N. A., Bickel, P. E., Cohen, S., Fisher, E. A., Galis, Z. S., Granneman, J. G., Lewandowski, E. D., Murphy, R., Olive, M., Schaffer, J. E., Schwartz-Longacre, L., Shulman, G. I., Walther, T. C., & Chen, J. (2018). Deciphering the role of lipid droplets in cardiovascular disease. Circulation, 138(3), 305-315. https://doi.org/10.1161/CIRCULATIONAHA.118.033704

Goldberg, IJ, Reue, K, Abumrad, NA, Bickel, PE, Cohen, S, Fisher, EA, Galis, ZS, Granneman, JG, Lewandowski, ED, Murphy, R, Olive, M, Schaffer, JE, Schwartz-Longacre, L, Shulman, GI, Walther, TC & Chen, J 2018, 'Deciphering the role of lipid droplets in cardiovascular disease', Circulation, vol. 138, no. 3, pp. 305-315. https://doi.org/10.1161/CIRCULATIONAHA.118.033704

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abstract = "Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.",

keywords = "Atherosclerosis, Heart failure, Metabolic syndrome, Obesity, Triglycerides",

author = "Goldberg, {Ira J.} and Karen Reue and Abumrad, {Nada A.} and Bickel, {Perry E.} and Sarah Cohen and Fisher, {Edward A.} and Galis, {Zorina S.} and Granneman, {James G.} and Lewandowski, {E. Douglas} and Robert Murphy and Michelle Olive and Schaffer, {Jean E.} and Lisa Schwartz-Longacre and Shulman, {Gerald I.} and Walther, {Tobias C.} and Jue Chen",

note = "Publisher Copyright: {\textcopyright} 2018 American Heart Association, Inc.",

year = "2018",

doi = "10.1161/CIRCULATIONAHA.118.033704",

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AU - Fisher, Edward A.

AU - Galis, Zorina S.

AU - Granneman, James G.

AU - Lewandowski, E. Douglas

AU - Murphy, Robert

AU - Olive, Michelle

AU - Schaffer, Jean E.

AU - Schwartz-Longacre, Lisa

AU - Shulman, Gerald I.

AU - Walther, Tobias C.

AU - Chen, Jue

PY - 2018

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N2 - Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.

AB - Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.

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KW - Metabolic syndrome

KW - Obesity

KW - Triglycerides

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Deciphering the role of lipid droplets in cardiovascular disease

Abstract

Keywords

ASJC Scopus subject areas

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