TY - JOUR
T1 - Cytosine arabinoside in the treatment of congenital cytomegalic inclusion disease
AU - McCracken, George H.
AU - Luby, James P.
AU - Plotkin, Stanley A.
PY - 1972/3
Y1 - 1972/3
N2 - Cytosine arabinoside (ARA-C) was used in the treatment of 3 infants with disseminated cytomegalovirus infection. The titer of cytomegalovirus was reduced in vitro 0 to 2 log10 TCID50 with 1.0 μg per millitier, and 2 to 3 log10 TCID50 with 10 and 100 μg per milliliter of ARA-C. The concentration of cytomegalovirus in the urine of the 3 patients was reduced 2 to 3 logs during therapy, but returned to pretreatment titers or higher within several weeks. Transient hematologic and hepatic toxicity were observed during therapy, and ARA-C had no appreciable beneficial effect on the clinical course of the infants.
AB - Cytosine arabinoside (ARA-C) was used in the treatment of 3 infants with disseminated cytomegalovirus infection. The titer of cytomegalovirus was reduced in vitro 0 to 2 log10 TCID50 with 1.0 μg per millitier, and 2 to 3 log10 TCID50 with 10 and 100 μg per milliliter of ARA-C. The concentration of cytomegalovirus in the urine of the 3 patients was reduced 2 to 3 logs during therapy, but returned to pretreatment titers or higher within several weeks. Transient hematologic and hepatic toxicity were observed during therapy, and ARA-C had no appreciable beneficial effect on the clinical course of the infants.
UR - http://www.scopus.com/inward/record.url?scp=0015309547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015309547&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(72)80515-8
DO - 10.1016/S0022-3476(72)80515-8
M3 - Article
C2 - 4334178
AN - SCOPUS:0015309547
SN - 0022-3476
VL - 80
SP - 488
EP - 495
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -