TY - JOUR
T1 - Cytomorphologic characteristics and differential diagnoses of lymphoepithelial carcinoma of the parotid
AU - Hipp, Jennifer A.
AU - Jing, Xin
AU - Zarka, Matthew A.
AU - Schmitt, Alessandra C.
AU - Siddiqui, Momin T.
AU - Wakely, Paul
AU - Bishop, Justin
AU - Ali, Syed Z.
N1 - Publisher Copyright:
© 2016 American Society of Cytopathology.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Introduction: Lymphoepithelial carcinoma of the salivary gland is an extremely rare neoplasm and is challenging to diagnose by fine needle aspiration (FNA). There are rare reports on the cytopathologic features of lymphoepithelial carcinoma, which may be mistaken for other high-grade salivary gland neoplasm or a metastasis to the salivary gland. Materials and methods: A retrospective review was undertaken of 7 cases of lymphoepithelial carcinoma of the parotid diagnosed on FNA with histologic confirmation from 4 major medical centers. Results: Cytomorphologic features of lymphoepithelial carcinoma include smears with moderate cellularity displaying a rich nonneoplastic population of lymphoplasmacytic cells admixed with tissue fragments of high grade, malignant undifferentiated epithelial cells with high nuclear to cytoplasm ratio, hyperchromasia, prominent nucleoli, and scant to abundant, indistinct cytoplasm. Discussion: Diagnostic pitfalls of lymphoepithelial carcinoma include metastatic squamous cell carcinoma, metastatic nasopharyngeal carcinoma, and other high grade primary salivary gland neoplasms. Recognizing this lesion may help guide clinicians to perform additional imaging studies to exclude a primary from other sites.
AB - Introduction: Lymphoepithelial carcinoma of the salivary gland is an extremely rare neoplasm and is challenging to diagnose by fine needle aspiration (FNA). There are rare reports on the cytopathologic features of lymphoepithelial carcinoma, which may be mistaken for other high-grade salivary gland neoplasm or a metastasis to the salivary gland. Materials and methods: A retrospective review was undertaken of 7 cases of lymphoepithelial carcinoma of the parotid diagnosed on FNA with histologic confirmation from 4 major medical centers. Results: Cytomorphologic features of lymphoepithelial carcinoma include smears with moderate cellularity displaying a rich nonneoplastic population of lymphoplasmacytic cells admixed with tissue fragments of high grade, malignant undifferentiated epithelial cells with high nuclear to cytoplasm ratio, hyperchromasia, prominent nucleoli, and scant to abundant, indistinct cytoplasm. Discussion: Diagnostic pitfalls of lymphoepithelial carcinoma include metastatic squamous cell carcinoma, metastatic nasopharyngeal carcinoma, and other high grade primary salivary gland neoplasms. Recognizing this lesion may help guide clinicians to perform additional imaging studies to exclude a primary from other sites.
KW - Ancillary studies
KW - Cytomorphology of lymphoepithelial carcinoma
KW - Fine needle aspiration
KW - Lymphoepithelial-like carcinoma
KW - Salivary glands lesions
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U2 - 10.1016/j.jasc.2015.09.216
DO - 10.1016/j.jasc.2015.09.216
M3 - Article
C2 - 31042496
AN - SCOPUS:84957851055
SN - 2213-2945
VL - 5
SP - 93
EP - 99
JO - Journal of the American Society of Cytopathology
JF - Journal of the American Society of Cytopathology
IS - 2
ER -