Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

H. Nagasawa; J. B. Little; W. C. Inkret; S. Carpenter; K. Thompson; M. R. Raju; D. J. Chen; G. F. Strniste

doi:10.1016/0165-7992(90)90134-6

Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

H. Nagasawa, J. B. Little, W. C. Inkret, S. Carpenter, K. Thompson, M. R. Raju, D. J. Chen, G. F. Strniste

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

CHO K-1 cells were irradiated during the G₁ phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.

Original language	English (US)
Pages (from-to)	233-238
Number of pages	6
Journal	Mutation Research Letters
Volume	244
Issue number	3
DOIs	https://doi.org/10.1016/0165-7992(90)90134-6
State	Published - Jul 1990

Keywords

Alpha-particle irradation, low doses
CHO K-1 cells
Plutonium-238, extremely low doses, alpha-particle irradation

ASJC Scopus subject areas

Medicine(all)

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10.1016/0165-7992(90)90134-6

Cite this

@article{0070e2ebfb0c42b8accd3f5d036a6ede,

title = "Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells",

abstract = "CHO K-1 cells were irradiated during the G1 phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.",

keywords = "Alpha-particle irradation, low doses, CHO K-1 cells, Plutonium-238, extremely low doses, alpha-particle irradation",

author = "H. Nagasawa and Little, {J. B.} and Inkret, {W. C.} and S. Carpenter and K. Thompson and Raju, {M. R.} and Chen, {D. J.} and Strniste, {G. F.}",

note = "Funding Information: This research was funded by the U.S. Department of Energy Contract W-7405-ENG-36 with the Los Alamos National Laboratory, by Los Alamos National Laboratory Institutional Research funds, and by grant CA47542 from the U.S. National Institutes of Health.",

year = "1990",

month = jul,

doi = "10.1016/0165-7992(90)90134-6",

language = "English (US)",

volume = "244",

pages = "233--238",

journal = "Mutation Research Letters",

issn = "0165-7992",

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T1 - Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

AU - Nagasawa, H.

AU - Little, J. B.

AU - Inkret, W. C.

AU - Carpenter, S.

AU - Thompson, K.

AU - Raju, M. R.

AU - Chen, D. J.

AU - Strniste, G. F.

N1 - Funding Information: This research was funded by the U.S. Department of Energy Contract W-7405-ENG-36 with the Los Alamos National Laboratory, by Los Alamos National Laboratory Institutional Research funds, and by grant CA47542 from the U.S. National Institutes of Health.

PY - 1990/7

Y1 - 1990/7

N2 - CHO K-1 cells were irradiated during the G1 phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.

AB - CHO K-1 cells were irradiated during the G1 phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.

KW - Alpha-particle irradation, low doses

KW - CHO K-1 cells

KW - Plutonium-238, extremely low doses, alpha-particle irradation

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Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

Abstract

Keywords

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