Cytodiagnosis of a primary effusion lymphoma: A case report

Manjunath S. Vadmal; Thorn F. Smilari; Judith P. Brody; Prasad Koduru; Steven I. Hajdu

doi:10.1159/000331619

Cytodiagnosis of a primary effusion lymphoma: A case report

Manjunath S. Vadmal, Thorn F. Smilari, Judith P. Brody, Prasad Koduru, Steven I. Hajdu

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for sudden-onset shortness of breath caused by a pleural effusion. Cytologic examination of the pleural fluid revealed medium to large atypical lymphocytes with a high mitosis rate, suspicious for lymphoma. Further diagnostic tests, such as immunophenotypic analysis and cytogenetic and molecular studies, confirmed the diagnosis of PEL. CONCLUSION: Cytopathologists and cytotechnologists should be aware of this new entity since additional studies are required for a definitive diagnosis.

Original language	English (US)
Pages (from-to)	374-376
Number of pages	3
Journal	Acta Cytologica
Volume	42
Issue number	2
DOIs	https://doi.org/10.1159/000331619
State	Published - 1998

Keywords

AIDS-associated lymphoma
Burkitt's translocation
Primary effusion lymphoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Access to Document

10.1159/000331619

Cite this

@article{cb951123a2594a8892c1b8953ad9876a,

title = "Cytodiagnosis of a primary effusion lymphoma: A case report",

abstract = "BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for sudden-onset shortness of breath caused by a pleural effusion. Cytologic examination of the pleural fluid revealed medium to large atypical lymphocytes with a high mitosis rate, suspicious for lymphoma. Further diagnostic tests, such as immunophenotypic analysis and cytogenetic and molecular studies, confirmed the diagnosis of PEL. CONCLUSION: Cytopathologists and cytotechnologists should be aware of this new entity since additional studies are required for a definitive diagnosis.",

keywords = "AIDS-associated lymphoma, Burkitt's translocation, Primary effusion lymphoma",

author = "Vadmal, {Manjunath S.} and Smilari, {Thorn F.} and Brody, {Judith P.} and Prasad Koduru and Hajdu, {Steven I.}",

year = "1998",

doi = "10.1159/000331619",

language = "English (US)",

volume = "42",

pages = "374--376",

journal = "Acta Cytologica",

issn = "0001-5547",

publisher = "Science Printers and Publishers Inc.",

number = "2",

}

TY - JOUR

T1 - Cytodiagnosis of a primary effusion lymphoma

T2 - A case report

AU - Vadmal, Manjunath S.

AU - Smilari, Thorn F.

AU - Brody, Judith P.

AU - Koduru, Prasad

AU - Hajdu, Steven I.

PY - 1998

Y1 - 1998

N2 - BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for sudden-onset shortness of breath caused by a pleural effusion. Cytologic examination of the pleural fluid revealed medium to large atypical lymphocytes with a high mitosis rate, suspicious for lymphoma. Further diagnostic tests, such as immunophenotypic analysis and cytogenetic and molecular studies, confirmed the diagnosis of PEL. CONCLUSION: Cytopathologists and cytotechnologists should be aware of this new entity since additional studies are required for a definitive diagnosis.

AB - BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for sudden-onset shortness of breath caused by a pleural effusion. Cytologic examination of the pleural fluid revealed medium to large atypical lymphocytes with a high mitosis rate, suspicious for lymphoma. Further diagnostic tests, such as immunophenotypic analysis and cytogenetic and molecular studies, confirmed the diagnosis of PEL. CONCLUSION: Cytopathologists and cytotechnologists should be aware of this new entity since additional studies are required for a definitive diagnosis.

KW - AIDS-associated lymphoma

KW - Burkitt's translocation

KW - Primary effusion lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0031954054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031954054&partnerID=8YFLogxK

U2 - 10.1159/000331619

DO - 10.1159/000331619

M3 - Article

C2 - 9568139

AN - SCOPUS:0031954054

SN - 0001-5547

VL - 42

SP - 374

EP - 376

JO - Acta Cytologica

JF - Acta Cytologica

IS - 2

ER -

Cytodiagnosis of a primary effusion lymphoma: A case report

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this