Cytochrome P450 and the arachidonate cascade

Jorge H. Capdevila; J R Falck; Ronald W. Estabrook

doi:10.1096/fasebj.6.2.1537463

Cytochrome P450 and the arachidonate cascade

Jorge H. Capdevila, J R Falck, Ronald W. Estabrook

Biochemistry

Research output: Contribution to journal › Review article › peer-review

276 Scopus citations

Abstract

Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

Original language	English (US)
Pages (from-to)	731-736
Number of pages	6
Journal	FASEB Journal
Volume	6
Issue number	2
DOIs	https://doi.org/10.1096/fasebj.6.2.1537463
State	Published - 1992

Keywords

Arachidonate
Eicosanoids
Epoxygenase
Omega oxidation
P450
Prostanoids Hydroxyeicosatetraenoic acids

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Genetics

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10.1096/fasebj.6.2.1537463

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abstract = "Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.",

keywords = "Arachidonate, Eicosanoids, Epoxygenase, Omega oxidation, P450, Prostanoids Hydroxyeicosatetraenoic acids",

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pages = "731--736",

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T1 - Cytochrome P450 and the arachidonate cascade

AU - Capdevila, Jorge H.

AU - Falck, J R

AU - Estabrook, Ronald W.

PY - 1992

Y1 - 1992

N2 - Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

AB - Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

KW - Arachidonate

KW - Eicosanoids

KW - Epoxygenase

KW - Omega oxidation

KW - P450

KW - Prostanoids Hydroxyeicosatetraenoic acids

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DO - 10.1096/fasebj.6.2.1537463

M3 - Review article

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AN - SCOPUS:0026569586

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EP - 736

JO - FASEB Journal

JF - FASEB Journal

IS - 2

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Cytochrome P450 and the arachidonate cascade

Abstract

Keywords

ASJC Scopus subject areas

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