Cytochrome P450 and the arachidonate cascade

Jorge H. Capdevila, J R Falck, Ronald W. Estabrook

Research output: Contribution to journalReview articlepeer-review

276 Scopus citations


Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

Original languageEnglish (US)
Pages (from-to)731-736
Number of pages6
JournalFASEB Journal
Issue number2
StatePublished - 1992


  • Arachidonate
  • Eicosanoids
  • Epoxygenase
  • Omega oxidation
  • P450
  • Prostanoids Hydroxyeicosatetraenoic acids

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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