Cystic hypersecretory carcinoma of the breast with Paget disease of the nipple: A diagnostic challenge

Sunati Sahoo, Purva Gopal, Lane Roland, Nancy Pile

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A unique case of cystic hypersecretory carcinoma in a 48-year-old woman who presented with a tender, palpable abnormality of the lower outer quadrant of her left breast in 2002 is described. Mammographic and ultrasound examinations showed heterogeneous, dense breast tissue with a focal asymmetric density and an ill-defined heterogenous hypoechoic area with anechoic spaces, respectively, that corresponded to the area of palpable abnormality. Although the imaging findings did not change significantly over 4 years, the patient complained of intermittent, spontaneous serous discharge from the left nipple and persistent induration and tenderness in the same area of the left breast. An ultrasound-guided core-needle biopsy of the lesion was performed at the last visit to rule out a malignant process. A left simple mastectomy showed a large multicystic lesion occupying most of the lower quadrants by a cystic hypersecretory carcinoma and Paget disease of the nipple.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number2
StatePublished - Apr 2008


  • Breast carcinoma
  • Cystic hypersecretory carcinoma
  • Paget disease

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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