Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia

Beth A. Lubeck; Philip E. Lapinski; Jennifer A. Oliver; Olga Ksionda; Luis F. Parada; Yuan Zhu; Ivan Maillard; Mark Chiang; Jeroen Roose; Philip D. King

doi:10.4049/jimmunol.1402639

Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia

Beth A. Lubeck, Philip E. Lapinski, Jennifer A. Oliver, Olga Ksionda, Luis F. Parada, Yuan Zhu, Ivan Maillard, Mark Chiang, Jeroen Roose, Philip D. King

Developmental Biology

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16 Scopus citations

Abstract

Ras GTPase-activating proteins (RasGAPs) inhibit signal transduction initiated through the Ras small GTPbinding protein. However, which members of the RasGAP family act as negative regulators of T cell responses is not completely understood. In this study, we investigated potential roles for the RasGAPs RASA1 and neurofibromin 1 (NF1) in T cells through the generation and analysis of T cell-specific RASA1 and NF1 doubledeficient mice. In contrast to mice lacking either RasGAP alone in T cells, double-deficient mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 gene. These findings highlight RASA1 and NF1 as cotumor suppressors in the T cell lineage.

Original language	English (US)
Pages (from-to)	31-35
Number of pages	5
Journal	Journal of Immunology
Volume	195
Issue number	1
DOIs	https://doi.org/10.4049/jimmunol.1402639
State	Published - Jul 1 2015

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.4049/jimmunol.1402639

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Lubeck, B. A., Lapinski, P. E., Oliver, J. A., Ksionda, O., Parada, L. F., Zhu, Y., Maillard, I., Chiang, M., Roose, J., & King, P. D. (2015). Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia. Journal of Immunology, 195(1), 31-35. https://doi.org/10.4049/jimmunol.1402639

Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia. / Lubeck, Beth A.; Lapinski, Philip E.; Oliver, Jennifer A. et al.
In: Journal of Immunology, Vol. 195, No. 1, 01.07.2015, p. 31-35.

Research output: Contribution to journal › Article › peer-review

Lubeck, BA, Lapinski, PE, Oliver, JA, Ksionda, O, Parada, LF, Zhu, Y, Maillard, I, Chiang, M, Roose, J & King, PD 2015, 'Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia', Journal of Immunology, vol. 195, no. 1, pp. 31-35. https://doi.org/10.4049/jimmunol.1402639

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title = "Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia",

abstract = "Ras GTPase-activating proteins (RasGAPs) inhibit signal transduction initiated through the Ras small GTPbinding protein. However, which members of the RasGAP family act as negative regulators of T cell responses is not completely understood. In this study, we investigated potential roles for the RasGAPs RASA1 and neurofibromin 1 (NF1) in T cells through the generation and analysis of T cell-specific RASA1 and NF1 doubledeficient mice. In contrast to mice lacking either RasGAP alone in T cells, double-deficient mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 gene. These findings highlight RASA1 and NF1 as cotumor suppressors in the T cell lineage.",

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Cutting edge: Codeletion of the ras GTPase-activating proteins (RasGAPs) neurofibromin 1 and p120 RasGAP in T cells results in the development of T cell acute lymphoblastic leukemia

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