TY - JOUR
T1 - Cutaneous signet-ring cell squamous cell carcinoma
AU - Findeis, Sarah K.
AU - Readinger, Allison
AU - Mitchell, James
AU - Agarwal, Atin
N1 - Publisher Copyright:
© 2020, Copyright © 2020 Baylor University Medical Center.
PY - 2020/7/2
Y1 - 2020/7/2
N2 - Cutaneous signet-ring cell squamous cell carcinoma (SRCSCC) is a rare variant, most commonly occurring in the head and neck. We report a case of a 66-year-old transgender woman with an ulcerated growing facial mass measuring 5.6 × 4.0 × 2.0 cm. Histological analysis showed features consistent with SRCSCC. Immunohistochemical analysis showed positive staining for high-molecular-weight cytokeratin, estrogen receptor (1-2+ in 10%), E-cadherin (mostly positive with partial loss), and p40 and negative staining for Ber EP-4, cytokeratin 7, low-molecular-weight cytokeratin, mucicarmine, Alcian blue PAS, HER2, and MUC4. The tumor had invaded the perineurium, lymphovascular spaces, and subcutaneum. Additionally, microsatellite instability testing was negative. This case adds to the limited knowledge of this poorly characterized entity.
AB - Cutaneous signet-ring cell squamous cell carcinoma (SRCSCC) is a rare variant, most commonly occurring in the head and neck. We report a case of a 66-year-old transgender woman with an ulcerated growing facial mass measuring 5.6 × 4.0 × 2.0 cm. Histological analysis showed features consistent with SRCSCC. Immunohistochemical analysis showed positive staining for high-molecular-weight cytokeratin, estrogen receptor (1-2+ in 10%), E-cadherin (mostly positive with partial loss), and p40 and negative staining for Ber EP-4, cytokeratin 7, low-molecular-weight cytokeratin, mucicarmine, Alcian blue PAS, HER2, and MUC4. The tumor had invaded the perineurium, lymphovascular spaces, and subcutaneum. Additionally, microsatellite instability testing was negative. This case adds to the limited knowledge of this poorly characterized entity.
KW - Signet-ring cell squamous cell carcinoma
KW - signet squamous cell
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U2 - 10.1080/08998280.2020.1747342
DO - 10.1080/08998280.2020.1747342
M3 - Article
C2 - 32675973
AN - SCOPUS:85083690899
SN - 0899-8280
VL - 33
SP - 424
EP - 426
JO - Baylor University Medical Center Proceedings
JF - Baylor University Medical Center Proceedings
IS - 3
ER -