Cutaneous manifestations of HIV Infection

Clay J Cockerell, Philip R. Cohen

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


We have a better understanding of the pathogenesis of skin diseases in patients with HIV infection. It is apparent that the effects of HIV on the immune system are much more complex than simple depletion of CD4 lymphocytes. Subsets of T-helper cells, referred to as Th1 and Th2, have been found to play significant roles in HIV infection and AIDS. Th1 cells predominate in the normal state in immunocompetent individuals. Th1 lymphocytes promote cellular immunity and produce interleukin (IL)-2, IL-12, and interferon gamma to eradicate infection. Th2 lymphocytes promote humoral immunity and produce IL-4, IL-5, IL-10, and allergic responses. Th1 cells suppress Th2 cells, and vice versa.

Original languageEnglish (US)
Title of host publicationMucocutaneous Manifestations of Viral Diseases
PublisherCRC Press
Number of pages90
ISBN (Electronic)9780203910733
ISBN (Print)9780824704506
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • General Medicine


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