Current status of small peripheral adenocarcinomas of the lung and their importance to pathologists

José I. López, Thomas V. Colby, Adi F. Gazdar

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


There has been a large amount of work done recently on small peripheral stage I adenocarcinomas that come to resection. Radiological (including proportion of ground glass opacity) and pathological features of these lesions (predominant bronchioloalveolar component, central scar with or without invasion <0.5 cm) have been shown to be prognostically favorable with cure rate approaching 100% in some series. Most of these studies emanate from Japan. The relevance of these studies to other parts of the world, particularly North America, is discussed in light of the fact that some recent chemotherapeutic studies with gefitinib have shown increased response in individuals of Asian origin, suggesting that some genetic differences may be significant. The relevance of these findings to pathologists and the pathological study of small peripheral adenocarcinomas from elsewhere in the world are discussed.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalAnnals of Diagnostic Pathology
Issue number2
StatePublished - Apr 2005


  • Adenocarcinoma
  • Atypical adenomatous hyperplasia
  • Bronchioloalveolar carcinoma
  • Lung cancer
  • Nonmucinous bronchioloalveolar carcinoma
  • Pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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