CSF neuropeptide Y in alcoholics and normal controls

Alec Roy, Wade Berrettini, Judith DeJong, Byron Adinoff, Bernard Ravitz, Markku Linnoila

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Neuropeptide Y is found in brain tissue. In dogs it has been shown to enhance activation of the hypothalamic-pituitary-adrenal axis by corticotropin- releasing hormone. It is localized in certain catecholamine neurons and to some extent colocalized with somatostatin. Disturbances of the central noradrenergic system may underlie some forms of alcoholism. Therefore, we compared male alcoholics and normal controls on cerebrospinal fluid (CSF) levels of neuropeptide Y. There was no significant difference between the two groups for neuropeptide Y. There was also no significant difference for CSF levels of growth hormone releasing hormone. However, there were significant positive correlations between CSF levels of neuropeptide Y and CSF levels of corticotropin- releasing hormone, somatostatin, and growth hormone releasing hormone.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalPsychiatry research
Issue number3
StatePublished - Sep 1990


  • Neuropeptide Y, alcoholics, controls, growth hormone releasing hormone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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