TY - JOUR
T1 - Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus
AU - Machius, Mischa
AU - Henry, Lisa
AU - Palnitkar, Maya
AU - Deisenhofer, Johann
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/10/12
Y1 - 1999/10/12
N2 - Nucleotide excision repair (NER) is the most important DNA-repair mechanism in living organisms. In prokaryotes, three enzymes forming the UvrABC system initiate NER of a variety of structurally different DNA lesions, UvrB, the central component of this system, is responsible for the ultimate DNA damage recognition and participates in the incision of the damaged DNA strand. The crystal structure of Thermus thermophilus UvrB reveals a core that is structurally similar to core regions found in helicases, where they constitute molecular motors. Additional domains implicated in binding to DNA and various components of the NER system are attached to this central core. The architecture and distribution of DNA binding sites suggest a possible model for the DNA damage recognition process.
AB - Nucleotide excision repair (NER) is the most important DNA-repair mechanism in living organisms. In prokaryotes, three enzymes forming the UvrABC system initiate NER of a variety of structurally different DNA lesions, UvrB, the central component of this system, is responsible for the ultimate DNA damage recognition and participates in the incision of the damaged DNA strand. The crystal structure of Thermus thermophilus UvrB reveals a core that is structurally similar to core regions found in helicases, where they constitute molecular motors. Additional domains implicated in binding to DNA and various components of the NER system are attached to this central core. The architecture and distribution of DNA binding sites suggest a possible model for the DNA damage recognition process.
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U2 - 10.1073/pnas.96.21.11717
DO - 10.1073/pnas.96.21.11717
M3 - Article
C2 - 10518516
AN - SCOPUS:0032717259
SN - 0027-8424
VL - 96
SP - 11717
EP - 11722
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 21
ER -