Abstract
Partin et al. present cryo-EM structures of the Microprocessor complex bound to a pri-miRNA, revealing how Drosha and DGCR8 recognize substrates and determine cleavage sites. Two dsRBDs form a molecular ruler to measure the stem length, and “Belt” and “Wedge” in Drosha play key roles in detecting the basal junction.
Original language | English (US) |
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Pages (from-to) | 411-422.e4 |
Journal | Molecular cell |
Volume | 78 |
Issue number | 3 |
DOIs | |
State | Published - May 7 2020 |
Keywords
- DGCR8
- Drosha
- Microprocessor
- RNA processing
- RNase III
- cryo-EM
- dsRBD
- microRNA
- pri-miRNA
- structure
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology