Crosslinked shells for nano-assembled capsules: A new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities

Annah Farashishiko; Sally E. Plush; Karley B. Maier; A. Dean Sherry; Mark Woods

doi:10.1039/c7cc00123a

Crosslinked shells for nano-assembled capsules: A new encapsulation method for smaller Gd³⁺-loaded capsules with exceedingly high relaxivities

Annah Farashishiko, Sally E. Plush, Karley B. Maier, A. Dean Sherry, Mark Woods

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Nano-assembled capsules can incorporate large payloads of high relaxivity Gd³⁺, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd³⁺ relaxivities (70.7 s^-1 mmolal^-1).

Original language	English (US)
Pages (from-to)	6355-6358
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	47
DOIs	https://doi.org/10.1039/c7cc00123a
State	Published - 2017

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Crosslinked shells for nano-assembled capsules: A new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities",

abstract = "Nano-assembled capsules can incorporate large payloads of high relaxivity Gd3+, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd3+ relaxivities (70.7 s-1 mmolal-1).",

author = "Annah Farashishiko and Plush, {Sally E.} and Maier, {Karley B.} and {Dean Sherry}, A. and Mark Woods",

note = "Funding Information: The authors thank the Oregon Nanoscience and Microtechnology Institute (ONAMI grant#: N00014-11-1-0193), the National Institutes of Health (R01-CA115531, P41-EB015908) and the Robert A. Welch Foundation (AT-584) for financial support of this work. Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc00123a",

language = "English (US)",

volume = "53",

pages = "6355--6358",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Crosslinked shells for nano-assembled capsules

T2 - A new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities

AU - Farashishiko, Annah

AU - Plush, Sally E.

AU - Maier, Karley B.

AU - Dean Sherry, A.

AU - Woods, Mark

N1 - Funding Information: The authors thank the Oregon Nanoscience and Microtechnology Institute (ONAMI grant#: N00014-11-1-0193), the National Institutes of Health (R01-CA115531, P41-EB015908) and the Robert A. Welch Foundation (AT-584) for financial support of this work. Publisher Copyright: © 2017 The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Nano-assembled capsules can incorporate large payloads of high relaxivity Gd3+, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd3+ relaxivities (70.7 s-1 mmolal-1).

AB - Nano-assembled capsules can incorporate large payloads of high relaxivity Gd3+, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd3+ relaxivities (70.7 s-1 mmolal-1).

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JO - Chemical Communications

JF - Chemical Communications

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Crosslinked shells for nano-assembled capsules: A new encapsulation method for smaller Gd³⁺-loaded capsules with exceedingly high relaxivities

Abstract

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