@article{630d2575d9864ae799d746a9f7d20d05,
title = "Crizotinib in patients with tumors harboring ALK or ROS1 rearrangements in the NCI-MATCH trial",
abstract = "The NCI-MATCH was designed to characterize the efficacy of targeted therapies in histology-agnostic driver mutation-positive malignancies. Sub-protocols F and G were developed to evaluate the role of crizotinib in rare tumors that harbored either ALK or ROS1 rearrangements. Patients with malignancies that progressed following at least one prior systemic therapy were accrued to the NCI-MATCH for molecular profiling, and those with actionable ALK or ROS1 rearrangements were offered participation in sub-protocols F or G, respectively. There were five patients who enrolled on Arm F (ALK) and four patients on Arm G (ROS1). Few grade 3 or 4 toxicities were noted, including liver test abnormalities, and acute kidney injury. For sub-protocol F (ALK), the response rate was 50% (90% CI 9.8–90.2%) with one complete response among the 4 eligible patients. The median PFS was 3.8 months, and median OS was 4.3 months. For sub-protocol G (ROS1) the response rate was 25% (90% CI 1.3–75.1%). The median PFS was 4.3 months, and median OS 6.2 months. Data from 3 commercial vendors showed that the prevalence of ALK and ROS1 rearrangements in histologies other than non-small cell lung cancer and lymphoma was rare (0.1% and 0.4% respectively). We observed responses to crizotinib which met the primary endpoint for ALK fusions, albeit in a small number of patients. Despite the limited accrual, some of the patients with these oncogenic fusions can respond to crizotinib which may have a therapeutic role in this setting.",
author = "Mansfield, {A. S.} and Z. Wei and R. Mehra and Shaw, {A. T.} and Lieu, {C. H.} and Forde, {P. M.} and Drilon, {A. E.} and Mitchell, {E. P.} and Wright, {J. J.} and N. Takebe and E. Sharon and D. Hovelson and S. Tomlins and J. Zeng and K. Poorman and N. Malik and Gray, {R. J.} and S. Li and McShane, {L. M.} and Rubinstein, {L. V.} and D. Patton and Williams, {P. M.} and Hamilton, {S. R.} and Conley, {B. A.} and Arteaga, {C. L.} and Harris, {L. N.} and O{\textquoteright}Dwyer, {P. J.} and Chen, {A. P.} and Flaherty, {K. T.}",
note = "Funding Information: This study was coordinated by the ECOG-ACRIN Cancer Research Group (Peter J. O{\textquoteright}Dwyer, MD and Mitchell D. Schnall, MD, PhD, Group Co-Chairs). This work was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: [U10CA180820, U10CA180794, UG1CA233329, UG1CA233302, UG1CA233180, UG1CA232760, UG1CA233324, UG1CA233196, UG1CA233341, and UG1CA233290]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. government. Administrative support for submission of the manuscript was provided by Bobbi Ann Jebens and Kenneth Hauer at Mayo Clinic. Funding Information: This study was coordinated by the ECOG-ACRIN Cancer Research Group (Peter J. O?Dwyer, MD and Mitchell D. Schnall, MD, PhD, Group Co-Chairs). This work was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: [U10CA180820, U10CA180794, UG1CA233329, UG1CA233302, UG1CA233180, UG1CA232760, UG1CA233324, UG1CA233196, UG1CA233341, and UG1CA233290]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. government. Administrative support for submission of the manuscript was provided by Bobbi Ann Jebens and Kenneth Hauer at Mayo Clinic. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41698-022-00256-w",
language = "English (US)",
volume = "6",
journal = "npj Precision Oncology",
issn = "2397-768X",
publisher = "Springer Nature",
number = "1",
}