TY - JOUR
T1 - Creating diseases to understand what prevents them
T2 - Genetic analysis of inflammation in the gastrointestinal tract
AU - Brandl, Katharina
AU - Beutler, Bruce
N1 - Funding Information:
The authors thank E.M. Moresco for critical reading of the manuscript and V. Webster for help with illustrations. This research was supported by the Crohn's and Colitis Foundation through a Career Development Award to K.B., and by NIH BAA Contract HHSN27220000038C. The authors have no conflicting financial interests.
PY - 2012/12
Y1 - 2012/12
N2 - Inflammatory bowel diseases (IBD), including both ulcerative colitis and Crohn's disease, are extremely variable in severity and have strong genetic components. In mice, several mutations are known to favor or inhibit intestinal inflammation. But a comprehensive picture of the pathogenesis of IBD cannot be assembled based on the limited information so far available from mouse genetic analyses, nor can human IBD be stringently ascribed to mutations known to be influential in mice. This review highlights recent progress made using mouse models created through a forward genetic approach towards the understanding of genes that normally prevent intestinal inflammation.
AB - Inflammatory bowel diseases (IBD), including both ulcerative colitis and Crohn's disease, are extremely variable in severity and have strong genetic components. In mice, several mutations are known to favor or inhibit intestinal inflammation. But a comprehensive picture of the pathogenesis of IBD cannot be assembled based on the limited information so far available from mouse genetic analyses, nor can human IBD be stringently ascribed to mutations known to be influential in mice. This review highlights recent progress made using mouse models created through a forward genetic approach towards the understanding of genes that normally prevent intestinal inflammation.
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U2 - 10.1016/j.coi.2012.10.005
DO - 10.1016/j.coi.2012.10.005
M3 - Review article
C2 - 23123276
AN - SCOPUS:84869863647
SN - 0952-7915
VL - 24
SP - 678
EP - 685
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -