TY - JOUR
T1 - Cortisol secretion and Alzheimer's disease progression
AU - Weiner, Myron F.
AU - Vobach, Stephen
AU - Olsson, Kirsten
AU - Svetlik, Doris
AU - Risser, Richard C.
N1 - Funding Information:
Supported in part by NIA 1-P30-AG12300, NIH M01-RR00633, and the Bob Smith, M.D. Foundation.
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Background: Mild hypercortisolemia is a frequent concomitant of Alzheimer's disease (AD). In an effort to ascertain the relationship between serum cortisol concentration (CORT) and disease progression, aging, and survival, we followed 9 persons with AD, ages from 56 to 84 years, from an original cohort of 19 enrollees with serial cognitive testing and CORT determinations. Methods: The cognitive instrument was a modification of the Alzheimer's Disease Assessment Scale-Cognitive (mADAS-COG). Serum cortisol determinations were performed at noon, and an Afternoon Cortisol Test (ACT) was used to obtain an estimate of average CORT. Results: Baseline 12:00 hours CORT but not ACT correlated significantly with the change in mADAS-COG (r = .90, p < .01). ACT levels increased as the mADAS-COG increased over time (p = .037), by 0.156 ± 0.06 μg/dL for each one-point increase (indicating greater impairment) in cognitive test score. ACT levels did not increase significantly simply with aging. For the entire cohort of 19 subjects, neither baseline ACT nor 12:00 hours CORT was significantly related to survival. Conclusions: Hypercortisolemia in AD appears related to the clinical progression of the disease, but not to aging or length of survival.
AB - Background: Mild hypercortisolemia is a frequent concomitant of Alzheimer's disease (AD). In an effort to ascertain the relationship between serum cortisol concentration (CORT) and disease progression, aging, and survival, we followed 9 persons with AD, ages from 56 to 84 years, from an original cohort of 19 enrollees with serial cognitive testing and CORT determinations. Methods: The cognitive instrument was a modification of the Alzheimer's Disease Assessment Scale-Cognitive (mADAS-COG). Serum cortisol determinations were performed at noon, and an Afternoon Cortisol Test (ACT) was used to obtain an estimate of average CORT. Results: Baseline 12:00 hours CORT but not ACT correlated significantly with the change in mADAS-COG (r = .90, p < .01). ACT levels increased as the mADAS-COG increased over time (p = .037), by 0.156 ± 0.06 μg/dL for each one-point increase (indicating greater impairment) in cognitive test score. ACT levels did not increase significantly simply with aging. For the entire cohort of 19 subjects, neither baseline ACT nor 12:00 hours CORT was significantly related to survival. Conclusions: Hypercortisolemia in AD appears related to the clinical progression of the disease, but not to aging or length of survival.
KW - Alzheimer's disease
KW - cortisol
KW - hypophyseal-pituitary-adrenal axis
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U2 - 10.1016/S0006-3223(97)00165-0
DO - 10.1016/S0006-3223(97)00165-0
M3 - Article
C2 - 9386855
AN - SCOPUS:0030661790
SN - 0006-3223
VL - 42
SP - 1030
EP - 1038
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 11
ER -