Abstract
Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11β-hydroxysteroid dehydrogenase (11β-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11β-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.
Original language | English (US) |
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Pages (from-to) | 411-418 |
Number of pages | 8 |
Journal | Endocrine Research |
Volume | 29 |
Issue number | 4 |
DOIs | |
State | Published - 2003 |
Keywords
- 11β-HSD
- Co-factor NADPH
- Cortisone reductase deficiency
- G6PDH
- H6PDH
- Visceral obesity
ASJC Scopus subject areas
- Endocrinology