TY - JOUR
T1 - Corticosteroids, immune suppression, and psychosis.
AU - Perantie, Dana C.
AU - Brown, E. Sherwood
PY - 2002/6
Y1 - 2002/6
N2 - The role of the immune system in psychiatric symptoms has been an area of much interest for many years. This review discusses medications and medical illnesses associated with immune system dysfunction, and their relationship to psychiatric symptoms, particularly psychosis. Medical illnesses including HIV infection, systemic lupus erythematosus (SLE), and Cushing's disease are all associated with psychiatric symptoms. In addition, high dosages of prescription corticosteroids (eg, prednisone and dexamethasone) are associated with mood changes, cognitive deficits, and even psychosis. However, the role of the immune system in mediating the psychiatric disturbances with each of these conditions is not clear. Directions for further research and treatment considerations are discussed.
AB - The role of the immune system in psychiatric symptoms has been an area of much interest for many years. This review discusses medications and medical illnesses associated with immune system dysfunction, and their relationship to psychiatric symptoms, particularly psychosis. Medical illnesses including HIV infection, systemic lupus erythematosus (SLE), and Cushing's disease are all associated with psychiatric symptoms. In addition, high dosages of prescription corticosteroids (eg, prednisone and dexamethasone) are associated with mood changes, cognitive deficits, and even psychosis. However, the role of the immune system in mediating the psychiatric disturbances with each of these conditions is not clear. Directions for further research and treatment considerations are discussed.
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U2 - 10.1007/s11920-002-0023-8
DO - 10.1007/s11920-002-0023-8
M3 - Review article
C2 - 12003678
AN - SCOPUS:0036615914
SN - 1523-3812
VL - 4
SP - 171
EP - 176
JO - Current psychiatry reports
JF - Current psychiatry reports
IS - 3
ER -