Corticosteroids, immune suppression, and psychosis.

Dana C. Perantie, E. Sherwood Brown

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The role of the immune system in psychiatric symptoms has been an area of much interest for many years. This review discusses medications and medical illnesses associated with immune system dysfunction, and their relationship to psychiatric symptoms, particularly psychosis. Medical illnesses including HIV infection, systemic lupus erythematosus (SLE), and Cushing's disease are all associated with psychiatric symptoms. In addition, high dosages of prescription corticosteroids (eg, prednisone and dexamethasone) are associated with mood changes, cognitive deficits, and even psychosis. However, the role of the immune system in mediating the psychiatric disturbances with each of these conditions is not clear. Directions for further research and treatment considerations are discussed.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalCurrent psychiatry reports
Issue number3
StatePublished - Jun 2002

ASJC Scopus subject areas

  • Psychiatry and Mental health


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